Cayman Chemical | Ciprostene (calcium salt) | Description • U-61431F; Ciprostene calcium (CAS 81703-55-1)

18216 Ciprostene (calcium salt)

U-61431F; Ciprostene calcium (CAS 81703-55-1)

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Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI₂. Ciprostene exhibits biological activity similar to PGI₂, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 µg/kg/min.¹ In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID₅₀ values of 9.1 µg/kg/min and 60 ng/ml, respectively.^1,2

1 Allan, G., Follenfant, M.J., Lidbury, P., et al. The cardiovascular and platelet actions of 9β-methyl carbacyclin (ciprostene), a chemically stable analogue of prostacyclin, in the dog and monkey. Br J Pharmacol 85 547-555 (1985).

2 Aristoff, P.A., Johnson, P.D., Harrison, A.W. Synthesis of 9-substituted carbacyclin analogues. J Org Chem 48 5341-5348 (1983).

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Pricing updated 2010-03-18.
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