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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Ciprostene (calcium salt)

Cayman Chemical Item Number 18216

U-61431F; Ciprostene calcium (CAS 81703-55-1)

Ciprostene (calcium salt) (CAS 81703-55-1)

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Description

Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 µg/kg/min.1 In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 µg/kg/min and 60 ng/ml, respectively.1,2

1 Allan, G., Follenfant, M.J., Lidbury, P., et al. The cardiovascular and platelet actions of 9β-methyl carbacyclin (ciprostene), a chemically stable analogue of prostacyclin, in the dog and monkey. Br J Pharmacol 85 547-555 (1985).

2 Aristoff, P.A., Johnson, P.D., and Harrison, A.W. Synthesis of 9-substituted carbacyclin analogues. J Org Chem 48 5341-5348 (1983).

Synonyms
  • U-61431F
  • Ciprostene calcium
Formal Name 6,​9α-​methylene-​9β-​methyl-​11α,​15S-​dihydroxy-​prosta-​5Z,​13E-​dien-​1-​oic acid,​ monocalcium salt
CAS Number 81703-55-1
Molecular Formula [C22H36O4]2 · Ca2+
Formula Weight 769.1
Formulation A crystalline solid
Purity ≥98%
Stability 6 months
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@H]​(O)​/C=C/[C@H]​1[C@H]​(O)​C[C@@]​2(C)​[C@@H]​1C/C(C2)​=C/CCCC([O-]​)​=O.[Ca+2]​

Ciprostene (calcium salt) is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $113.00 $0.00
5 mg $509.00 $0.00
10 mg $904.00 $0.00
50 mg $3,995.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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