Cayman Chemical | Prostaglandin I2 (sodium salt) | Description • Prostacyclin (sodium salt); Epoprostenol (sodium salt); PGI2 (Na salt) (CAS 61849-14-7)

18220 Prostaglandin I₂ (sodium salt)

Prostacyclin (sodium salt); Epoprostenol (sodium salt); PGI₂ (Na salt) (CAS 61849-14-7)

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For active pharmaceutical ingredients (APIs) related to Prostaglandin I₂ (sodium salt), see Cayman Pharma Epoprostenol.

Prostaglandin I 2 (PGI₂) is an unstable cyclooxygenase metabolite detected first in vascular endothelial cells.^1,2,3 It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC₅₀ of 5 nM.⁴ PGI₂ is stable in basic buffers (pH=8), but it is rapidly hydrolyzed to 6-keto PGF_1α in neutral or acidic solutions. The half-life is short both in vivo and in vitro, ranging from 30 seconds to a few minutes. PGI₂ is administered by continuous infusion in humans for the treatment of idiopathic pulmonary hypertension.⁵

1 Moncada, S., Gryglewski, R., Bunting, S., et al. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263 663-665 (1976).

2 Johnson, R.A., Morton, D.R., Kinner, J.H., et al. The chemical structure of prostaglandin X (prostacyclin). Prostaglandins 12 915-928 (1976).

3 Stehle, R.G. Physical chemistry, stability, and handling of prostaglandins E₂, F_2α, D₂ and I₂: A critical summary. Methods Enzymol 86 436-459 (1982).

4 Aristoff, P.A., Johnson, P.D., Harrison, A.W. Synthesis of 9-substituted carbacyclin analogues. J Org Chem 48 5341-5348 (1983).

5 McLaughlin, V.V., Genthner, D.E., Panella, M.M., et al. Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension. N Engl J Med 338 273-277 (1998).

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Pricing updated 2010-03-12.
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