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Piriprost (potassium salt)

Cayman Chemical Item Number 18228

U-60257B (CAS 88851-62-1)

Piriprost (potassium salt) (CAS 88851-62-1)

See more	Prostaglandins (513)

Description

Piriprost is a structural analog of prostaglandin I₂ (PGI₂) with low IP receptor-mediated activity. Piriprost inhibits 5-lipoxygenase with an IC₅₀ around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells.¹ Piriprost inhibits the release of histamine and leukotrienes from isolated porcine lung cells with an IC₅₀ of 0.11 µM, implicating its role in inflammation and allergic responses.²

1 Cejic, S.S., and Kennedy, T.G. Examination of the effects of piriprost (U-60, 257B) on alkaline phosphatase activity of rat endometrial stromal cells in vitro. Prostaglandins 42 179-189 (1991).

2 McCormack, D.G., and Peterson, N.A.M. The contrasting influence of two lipoxygenase inhibitors on hypoxic pulmonary vasoconstriction in anesthetized pigs. Am Rev Respir Dis 139 100-105 (1989).

Synonyms	U-60257B
Formal Name	1,4(R),5(R),6-tetrahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-1-octenyl]-1-phenyl-cyclopenta[b]pyrrole-2-pentanoic acid, monopotassium salt
CAS Number	88851-62-1
Molecular Formula	C₂₅H₃₂NO₄K
Formula Weight	449.6
Formulation	A crystalline solid
Purity	>98%
λ_max	239 nm
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC2=C1C=C(CCCC([O-])=O)N2C3=CC=CC=C3.[K+]

Background Reading

Cejic, S.S., and Kennedy, T.G. Examination of the effects of piriprost (U-60, 257B) on alkaline phosphatase activity of rat endometrial stromal cells in vitro. Prostaglandins 42 179-189 (1991).

McCormack, D.G., and Peterson, N.A.M. The contrasting influence of two lipoxygenase inhibitors on hypoxic pulmonary vasoconstriction in anesthetized pigs. Am Rev Respir Dis 139 100-105 (1989).

Piriprost (potassium salt) is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$41.00		$0.00
5 mg	$185.00		$0.00
10 mg	$328.00		$0.00
50 mg	$1,435.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Lipoxygenase Inhibitor Screening Assay Kit

REV 5901

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