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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Carbocyclic Thromboxane A2

Cayman Chemical Item Number 19010

CTA2; Carbocyclic TXA2 (CAS 74034-56-3)

Carbocyclic Thromboxane A2 (CAS 74034-56-3)

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Description

CTA2 is a stable analog of TXA2. CTA2 is a potent coronary vasoconstrictor and is effective at concentrations as low as 1 nM in cat coronary arteries.1 Unlike other vascular TP receptor agonists, CTA2 is a potent inhibitor of prostanoid-induced platelet aggregation. It inhibits arachidonic acid-induced aggregation with an IC50 value of 4-5 µM. CTA2 also exhibits selective and dose-dependent inhibition of TXB2 synthesis in rabbit platelets at concentrations between 1 and 100 µM.1

1 Lefer, A.M., Smith, E.F., Araki, H., et al. Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane A2, a stable analog of thromboxane A2. Proc Natl Acad Sci USA 77 1706-1710 (1980).

Synonyms
  • CTA2
  • Carbocyclic TXA2
Formal Name 9α,​11α-​methylene-​15S-​hydroxy-​11a-​deoxy-​11a-​methylene-​thromba-​5Z,​13E-​dien-​1-​oic acid
CAS Number 74034-56-3
Molecular Formula C22H36O3
Formula Weight 348.5
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@H]​(O)​/C=C/[C@H]​1C[C@H]​2C[C@H]​(C2)​[C@@H]​1C/C=C\CCCC(O)​=O

Background Reading

Smith, E.F., Lefer, A.M., and Nicolaou, K.C. Mechanism of coronary vasoconstriction induced by carbocyclic thromboxane A2. Am J Physiol 240 H493-H497 (1981).

Lefer, A.M., Smith, E.F., Araki, H., et al. Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane A2, a stable analog of thromboxane A2. Proc Natl Acad Sci USA 77 1706-1710 (1980).

Carbocyclic Thromboxane A2 is available in the following screening library:

Size Price Quantity Subtotal
100 µg $27.00 $0.00
500 µg $122.00 $0.00
1 mg $216.00 $0.00
5 mg $945.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Pinane Thromboxane A2

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