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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

I-SAP

Cayman Chemical Item Number 19021

Iodophenyl sulfonyl amino pinane Thromboxane A2; Iodophenyl sulfonyl amino pinane TXA2 (CAS 133538-58-6)

I-SAP (CAS 133538-58-6)

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Description

I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM. I-SAP binds to human platelets with the maximum binding obtained between pH 6.5 and pH 7.4. In washed human platelets, the Kd for I-SAP is 468 pM at pH 7.4 and 490 pM at pH 6.5.1

1 Naka, M., Mais, D.E., Morinelli, T.A., et al. 7-[(1R,2S,3S,5R)-6,6-Dimethyl-3-(4-iodobenzenesulfonylamino)bicyclo[3.1.1]hept-2-yl]-5(Z)-heptenoic acid: A novel high-affinity radiolabeled antagonist for platelet thromboxane A2/prostaglandin H2 receptors. J Pharmacol Exp Ther 262 632-637 (1992).

Synonyms
  • Iodophenyl sulfonyl amino pinane Thromboxane A2
  • Iodophenyl sulfonyl amino pinane TXA2
Formal Name (Z)-​[3S-​[1α,​2α,​3β,​5α]]-​7-​[3-​[[(4-​iodophenyl)sulfonyl]amino]-​6,​6-​dimethylbicyclo[3.1.1]hept-​2-​yl]-​5-​heptenoic acid
CAS Number 133538-58-6
Molecular Formula C22H30INO4S
Formula Weight 531.4
Formulation A solution in ethanol
Purity ≥98%
λmax 249 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC1(C)​[C@@H]​2[C@H]​(C/C=C\CCCC(O)​=O)​[C@@H]​(N([H]​)​S(C3=CC=C(I)​C=C3)​(=O)​=O)​C[C@H]​1C2

Background Reading

Naka, M., Mais, D.E., Morinelli, T.A., et al. 7-[(1R,2S,3S,5R)-6,6-Dimethyl-3-(4-iodobenzenesulfonylamino)bicyclo[3.1.1]hept-2-yl]-5(Z)-heptenoic acid: A novel high-affinity radiolabeled antagonist for platelet thromboxane A2/prostaglandin H2 receptors. J Pharmacol Exp Ther 262 632-637 (1992).

Mais, D.E., True, T.A., and Martinelli, M.J. Characterization by photoaffinity labelling of the human platelet thromboxane A2/prostaglandin H2 receptor: Evidence for N-linked glycosylation. Eur J Pharmacol 227 267-274 (1992).

I-SAP is available in the following screening library:

Size Price Quantity Subtotal
100 µg $59.00 $0.00
500 µg $266.00 $0.00
1 mg $472.00 $0.00
5 mg $2,065.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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