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SQ 29,548

Cayman Chemical Item Number 19025

(CAS 98672-91-4)

SQ 29,548 (CAS 98672-91-4)

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Description

SQ 29,548 is a highly selective TP receptor antagonist which binds to the human recombinant TP receptor with a Ki of 4.1 nM.1 It inhibits the aggregation of washed human platelets induced by U-46619 with an IC50 of 0.06 µM.2 It antagonizes U-46619 induced contraction of rat and guinea pig tracheal, arterial, and venous smooth muscles with drug/receptor dissociation constants (KB) in the range of 0.5-1.7 nM.3 SQ 29,548 also inhibits the contraction of rat vascular smooth muscle induced by 8-iso PGF2α.4

1 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

2 Ogletree, M.L., Harris, D.N., Greenberg, R., et al. Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist. J Pharmacol Exp Ther 234 435-441 (1985).

3 Ogletree, M.L., and Allen, G.T. Interspecies differences in thromboxane receptors: Studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J Pharmacol Exp Ther 260 789-794 (1992).

4 Fukunaga, M., Makita, N., Roberts, L.J., et al. Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells. Am J Physiol 264 C1619-C1624 (1993).

Formal Name [1S-​[1α,​2α(Z),​3α,​4α]]-​7-​[3-​[[2-​[(phenylamino)carbonyl]hydrazino]methyl]-​7-​oxabicyclo[2.2.1]hept-​2-​yl]-​5-​heptenoic acid
CAS Number 98672-91-4
Molecular Formula C21H29N3O4
Formula Weight 387.5
Formulation A crystalline solid
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC(=O)​CCC/C=C\CC1C2CCC(O2)​C1CNNC(=O)​Nc1ccccc1

Background Reading

Fukunaga, M., Makita, N., Roberts, L.J., et al. Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells. Am J Physiol 264 C1619-C1624 (1993).

Ogletree, M.L., and Allen, G.T. Interspecies differences in thromboxane receptors: Studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J Pharmacol Exp Ther 260 789-794 (1992).

Komiotis, D., Lim, C.T., Dieter, J.P., et al. PGH2 analogs as potential antiplatelet derivatives. J Med Chem 35 3033-3039 (1992).

Ogletree, M.L., Harris, D.N., Greenberg, R., et al. Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist. J Pharmacol Exp Ther 234 435-441 (1985).

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SQ 29,548 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $59.00 $0.00
5 mg $266.00 $0.00
10 mg $472.00 $0.00
100 mg $3,540.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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BM 567
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U-46619
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