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6α-hydroxy Paclitaxel

Cayman Chemical Item Number 19027

(CAS 153212-75-0)

6α-hydroxy Paclitaxel (CAS 153212-75-0)

See more	Cytochrome P450 (88) Metabolism (139)

Description

6α-hydroxy Paclitaxel is a CYP2C8 metabolite of paclitaxel.^1,2,3

1 Cresteil, T., Monsarrat, B., Dubois, J., et al. Regioselective metabolism of taxoids by human CYP3A4 and 2C8: Structure-activity relationship. Drug Metab Dispos 30 438-445 (2002).

2 Kumar, G.N., Oatis, J.E., Thornburg, K.R., et al. 6 alpha-Hydroxytaxol: Isolation and identification of the major metabolite of taxol in human liver microsomes. Drug Metab Dispos 22 177-179 (1994).

3 Rahman, A., Korzekwa, K.R., Grogan, J., et al. Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human P450 2C8. Cancer Res 54 5543-5546 (1994).

Formal Name	β-(benzoylamino)-α-hydroxy-(2aR,3S,4R,4aS,6R,9S,11S,12S,12aR,12bS,)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-3,4,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester-benzenepropanoic acid
CAS Number	153212-75-0
Molecular Formula	C₄₇H₅₁NO₁₅
Formula Weight	869.9
Formulation	A crystalline solid
Purity	≥97%
Stability	1 year
Storage	4°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(N([H])[C@@H](C1=CC=CC=C1)[C@@H](O)C(O[C@@H]2C(C)=C([C@@H](OC(C)=O)C([C@@]3(C)C4[C@](OC(C)=O)(CO5)[C@H]5[C@@H](O)[C@@H]3O)=O)C(C)(C)[C@](O)([C@H]4OC(C6=CC=CC=C6)=O)C2)=O)C7=CC=CC=C7

Background Reading

Cresteil, T., Monsarrat, B., Dubois, J., et al. Regioselective metabolism of taxoids by human CYP3A4 and 2C8: Structure-activity relationship. Drug Metab Dispos 30 438-445 (2002).

Rahman, A., Korzekwa, K.R., Grogan, J., et al. Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human P450 2C8. Cancer Res 54 5543-5546 (1994).

Kumar, G.N., Oatis, J.E., Thornburg, K.R., et al. 6 alpha-Hydroxytaxol: Isolation and identification of the major metabolite of taxol in human liver microsomes. Drug Metab Dispos 22 177-179 (1994).

Size	Price	Quantity	Subtotal
20 nmol	$202.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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