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Thromboxane B2

Cayman Chemical Item Number 19030

TXB2 (CAS 54397-85-2)

Thromboxane B2 (CAS 54397-85-2)

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Description

TXB2 is a stable, biologically inert metabolite formed from the non-enzymatic hydrolysis of TXA2, which has a half-life of about 30 seconds.1 Urinary analysis of TXB2 accurately reflects intrarenal TXA2 synthesis,2 while measurement of 11-dehydro and 2,3-dinor thromboxane metabolites gives the best estimate of systemic TXA2 secretion.3,4

1 Needleman, P., Moncada, S., Bunting, S., et al. Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Nature 261 558-560 (1976).

2 Patrono, C., Ciabattoni, G., Patrignani, P., et al. Evidence for a renal origin of urinary thromboxane B2 in health and disease. Adv Prostaglandin Thromboxane Leukot Res 11 493-498 (1983).

3 Lawson, J.A., Patrono, C., Ciabattoni, G., et al. Long-lived enzymatic metabolites of thromboxane B2 in the human circulation. Anal Biochem 155 198-205 (1986).

4 Patrono, C., Ciabattoni, G., Pugliese, F., et al. Estimated rate of thromboxane secretion into the circulation of normal humans. J Clin Invest 77 590-594 (1986).

Synonyms
  • TXB2
Formal Name 9α,​11,​15S-​trihydroxythromba-​5Z,​13E-​dien-​1-​oic acid
CAS Number 54397-85-2
Molecular Formula C20H34O6
Formula Weight 370.5
Formulation A crystalline solid
Purity ≥99%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCC(O)​/C=C/[C@H]​1OC(O)​CC(O)​C1C/C=C\CCCC(=O)​O

Background Reading

Needleman, P., Moncada, S., Bunting, S., et al. Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Nature 261 558-560 (1976).

Patrono, C., Ciabattoni, G., Pugliese, F., et al. Estimated rate of thromboxane secretion into the circulation of normal humans. J Clin Invest 77 590-594 (1986).

Patrono, C., Ciabattoni, G., Patrignani, P., et al. Evidence for a renal origin of urinary thromboxane B2 in health and disease. Adv Prostaglandin Thromboxane Leukot Res 11 493-498 (1983).

Lawson, J.A., Patrono, C., Ciabattoni, G., et al. Long-lived enzymatic metabolites of thromboxane B2 in the human circulation. Anal Biochem 155 198-205 (1986).

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Thromboxane B2 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $50.00 $0.00
5 mg $225.00 $0.00
10 mg $400.00 $0.00
50 mg $1,750.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Thromboxane B2 EIA Kit
Thromboxane B2 Lipid Maps MS Standard
Thromboxane B2 Quant-PAK
Tranilast
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