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I-BOP Exclusive

Cayman Chemical Item Number 19600

(CAS 128719-90-4)

I-BOP (CAS 128719-90-4)

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Description

I-BOP is a potent agonist of TP receptor-mediated platelet aggregation and vascular smooth muscle contraction.1 I-BOP induces human platelet aggregation with EC50 values of 0.34 nM and 0.174 nM at pH 7.4 and pH 6.0, respectively.2

1 Morinelli, T.A., Mais, D.E., Oatis, J.E., et al. I-BOP, the most potent radiolabelled agonist for the TXA2/PGH2 receptor. Adv Prostaglandin Thromboxane Leukot Res 20 102-109 (1990).

2 Mayeux, P.R., Morinelli, T.A., Williams, T.C., et al. Differential effect of pH on thromboxane A2/prostaglandin H2 receptor agonist and antagonist binding in human platelets. J Biol Chem 266 13752-13758 (1991).

Formal Name [1S-​[1α,​2α(Z),​3β(1E,​3S*),​4α]]-​7-​[3-​[3-​hydroxy-​4-​(4-​iodophenoxy)-​1-​butenyl]-​7-​oxabicyclo[2.2.1]hept-​2-​yl]-​5-​heptenoic acid
CAS Number 128719-90-4
Molecular Formula C23H29IO5
Formula Weight 512.4
Formulation A solution in ethanol
Purity ≥95%
λmax 234 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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IC1=CC=C(C=C1)​OC[C@H]​(O)​/C=C/[C@@H]​2[C@H]​(C/C=C\CCCC(O)​=O)​[C@@H]​3CC[C@H]​2O3

Background Reading

Saussy, D.L., Mais, D.E., Dubé, G.P., et al. Characterization of a thromboxane A2/prostaglandin H2 receptor in guinea pig lung membranes using a radioiodinated thromboxane mimetic. Mol Pharmacol 39 72-78 (1991).

Masuda, A., Mais, D.E., Oatis, J.E., et al. Platelet and vascular thromboxane A2/prostaglandin H2 receptors. Evidence for different subclasses in the rat. Biochem Pharmacol 42 537-544 (1991).

Buzzard, C.J., Pfister, S.L., Halushka, P.V., et al. Decrease in vascular TXA2 mimetic. Am J Physiol 266 H2320-H2326 (1994).

Morinelli, T.A., Mais, D.E., Oatis, J.E., et al. I-BOP, the most potent radiolabelled agonist for the TXA2/PGH2 receptor. Adv Prostaglandin Thromboxane Leukot Res 20 102-109 (1990).

Mayeux, P.R., Morinelli, T.A., Williams, T.C., et al. Differential effect of pH on thromboxane A2/prostaglandin H2 receptor agonist and antagonist binding in human platelets. J Biol Chem 266 13752-13758 (1991).

Bowling, N., Dubé, G.P., Kurtz, W.L., et al. Characterization of thromboxane A2/prostaglandin H2 binding sites in guinea pig cardiac membrane preparations. J Mol Cell Immunol 26 915-923 (1994).

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I-BOP is available in the following screening library:

Size Price Quantity Subtotal
100 µg $64.00 $0.00
500 µg $288.00 $0.00
1 mg $512.00 $0.00
5 mg $2,240.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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