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DISBAC10

Cayman Chemical Item Number 200280

(CAS 169211-45-4)

DISBAC10 (CAS 169211-45-4)

See more	Fluorescence (90)

Description

DISBAC10 is a fluorophore, which can be used in the study of cellular membrane electrical activity. In a resting polarized cell, DISBAC10 resides on the outer leaflet of the membrane where it can accept photons from excited fluorescein-labeled proteins and re-emit the photons at a higher wavelength (fluorescence resonance energy transfer - FRET). Depolarization of the cell causes rapid translocation of DISBAC10 to the inner leaflet of the membrane, thereby increasing the distance between fluorophores and reducing the FRET. DISBAC10 can also be useful with fluorescein-labeled antibodies or specific receptor ligands to visualize specific cell classes.¹

1 González, J., and Tsien, R.Y. Voltage sensing by fluorescence resonance energy transfer in single cells. Biophys J 69 1272-1280 (1995).

Formal Name	1,3-didecyl-5-[3-(1,3-didecylhexahydro-4,6-dioxo-2-thioxo-5-pyrimidinyl)-2-propenylidene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
CAS Number	169211-45-4
Molecular Formula	C₅₁H₈₈N₄O₄S₂
Formula Weight	885.4
Formulation	A solution in methyl acetate
Purity	≥98%
λ_max	541 nm
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCCCN1C(O)C(\C=C\C=C2C(=O)N(CCCCCCCCCC)C(=S)N(CCCCCCCCCC)C2=O)C(=O)N(CCCCCCCCCC)C1=S

Background Reading

González, J., and Tsien, R.Y. Voltage sensing by fluorescence resonance energy transfer in single cells. Biophys J 69 1272-1280 (1995).

Size	Price	Quantity	Subtotal
1 mg	$54.00		$0.00
5 mg	$243.00		$0.00
10 mg	$432.00		$0.00
50 mg	$1,890.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

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