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Leukotriene B3

Cayman Chemical Item Number 20109

LTB3 (CAS 88099-35-8)

Leukotriene B3 (CAS 88099-35-8)

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Description

LTB3 is the LTA hydrolase metabolite of LTA3 in the leukotriene biosynthetic pathway. LTB3 and LTB4 are equipotent in their pro-inflammatory effects.1,2 However, LTB3 is five times less potent than LTB4 in eliciting chemotaxis of human neutrophils.1

1 Lee, T.H., Sethi, T., Crea, A.E.G., et al. Characterization of leukotriene B3: Comparison of its biological activities with leukotriene B4 and leukotriene B5 in complement receptor enhancement, lysozyme release and chemotaxis of human neutrophils. Clin Sci 74 467-475 (1988).

2 Shimazaki, T., Kobayashi, Y., Sato, F., et al. Some newly synthesized leukotriene B4 analogs inhibit LTB4-induced lysozyme release from rat polymorphonuclear leukocytes. Prostaglandins 39 459-467 (1990).

Synonyms
  • LTB3
Formal Name 5S,​12R-​dihydroxy-​6Z,​8E,​10E-​eicosatrienoic acid
CAS Number 88099-35-8
Molecular Formula C20H34O4
Formula Weight 338.5
Formulation A solution in ethanol
Purity >97%
λmax 270 nm
ε 50
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCCCC[C@@H]​(O)​/C=C/C=C\C=C\[C@@H]​(O)​CCCC(=O)​O

Background Reading

Lee, T.H., Sethi, T., Crea, A.E.G., et al. Characterization of leukotriene B3: Comparison of its biological activities with leukotriene B4 and leukotriene B5 in complement receptor enhancement, lysozyme release and chemotaxis of human neutrophils. Clin Sci 74 467-475 (1988).

Shimazaki, T., Kobayashi, Y., Sato, F., et al. Some newly synthesized leukotriene B4 analogs inhibit LTB4-induced lysozyme release from rat polymorphonuclear leukocytes. Prostaglandins 39 459-467 (1990).
Size Price Quantity Subtotal
25 µg $118.00 $0.00
50 µg $224.00 $0.00
100 µg $425.00 $0.00
500 µg $1,888.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

12-epi Leukotriene B3
Leukotriene A3 methyl ester
Leukotriene B4

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