Leukotriene B4 Ethanolamide

Leukotriene B₄ Ethanolamide

Cayman Chemical Item Number 20112

LTB₄-EA

Description

The effects of Leukotriene B₄ (LTB₄) are mediated by two known receptors, BLT₁ and BLT₂.^1,2 LTB₄ is a high affinity ligand for BLT₁, and many of its pro-inflammatory effects are believed to be transduced through this receptor. The BLT₂ is more enigmatic, in that LTB₄ is not a high-affinity ligand, nor is it clear that BLT₂ activation promotes inflammation. LTB₄ ethanolamide (LTB₄-EA) is a theoretical 5-LO metabolite of arachidonoyl ethanolamide (AEA). In CHO cells transfected with human BLTR1, LTB₄-EA was a potent antagonist with about three times greater affinity for the receptor than LTB₄ (K_i = 1.22 nM versus 3.88 nM). LTB₄-EA antagonizes the LTB₄-induced contractions of guinea pig lung parenchyma with an EC₅₀ of 10 nM.³ LTB₄-EA thus represents a potential endogenous anti-inflammatory compound functioning as a natural antagonist of BLTR1.

1 Yokomizo, T., Izumi, T., Chang, K., et al. A G-protein-coupled receptor for leukotriene B₄ that mediates chemotaxis. Nature 387 620-624 (1997).

2 Yokomizo, T., Kato, K., Terawaki, K., et al. A second leukotriene B₄ receptor, BLT₂: A new therapeutic target in inflammation and immunological disorders. J Exp Med 193 421-431 (2000).

3 McHugh, D., McMaster, S., and Ross, R. Pharmacological characterization of LTB₄ ethanolamide: Interaction with leukotriene (BLT) and vanilloid (TRPV1) receptors. 121 (2003).

Synonyms

LTB4-EA

Formal Name

N-(2-hydroxyethyl)-5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenamide

Molecular Formula

C₂₂H₃₇NO₄

Formula Weight

379.5

Formulation

A solution in ethanol

Purity

>97%

λ_max

270 nm

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

SMILES

Copy SMILES to clipboard

CCCCC/C=C\C[C@@H](O)/C=C/C=C\C=C\[C@@H](O)CCCC(=O)NCCO

Background Reading

Yokomizo, T., Izumi, T., Chang, K., et al. A G-protein-coupled receptor for leukotriene B₄ that mediates chemotaxis. Nature 387 620-624 (1997).

Yokomizo, T., Kato, K., Terawaki, K., et al. A second leukotriene B₄ receptor, BLT₂: A new therapeutic target in inflammation and immunological disorders. J Exp Med 193 421-431 (2000).

McHugh, D., McMaster, S., and Ross, R. Pharmacological characterization of LTB₄ ethanolamide: Interaction with leukotriene (BLT) and vanilloid (TRPV1) receptors. 121 (2003).

Leukotriene B4 Ethanolamide is available in the following screening library:

Bio-active Lipid II Screening Library (96-Well)

Size

Price

Quantity

Subtotal

25 µg 
$112.00

$0.00

50 µg 
$213.00

$0.00

100 µg 
$403.00

$0.00

500 µg 
$1,792.00

$0.00

Bulk
Contact

Cart Total

$0.00

Other Resources

Management Team Company Profile Company History ChemAssistant Tools FAQs

Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases

Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule

Order Terms Browser Recommendation Privacy Statement Site Map

Leukotriene B₄ Ethanolamide