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Leukotriene B4-3-aminopropylamide

Cayman Chemical Item Number 20114

LTB4-3-aminopropylamide (CAS 89596-43-0)

Leukotriene B4-3-aminopropylamide (CAS 89596-43-0)

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Description

The effects of leukotriene B4 (LTB4) are mediated by two receptors, BLT1 and BLT2.1,2 LTB4-3-aminopropylamide is an analog of LTB4 that exhibits potent and selective binding to the BLT1 receptor, having Ki values of 5.1 and 1,227 nM at BLT1 and BLT2, respectively.3

1 Yokomizo, T., Izumi, T., Chang, K., et al. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 387 620-624 (1997).

2 Yokomizo, T., Kato, K., Terawaki, K., et al. A second leukotriene B4 receptor, BLT2: A new therapeutic target in inflammation and immunological disorders. J Exp Med 193 421-431 (2000).

3 Wang, S., Gustafson, E., Pang, L., et al. A novel hepatointestinal leukotriene B4 receptor. J Biol Chem 275 40686-40694 (2000).

Synonyms
  • LTB4-3-aminopropylamide
Formal Name N-​(3-​aminopropyl)-​5S,​12R-​dihydroxy-​6Z,​8E,​10E,​14Z-​eicosatetraenamide
CAS Number 89596-43-0
Molecular Formula C23H40N2O3
Formula Weight 392.6
Formulation A solution in ethanol
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C[C@@H]​(O)​/C=C/C=C\C=C\[C@@H]​(O)​CCCC(=O)​NCCCN

Background Reading

Yokomizo, T., Kato, K., Terawaki, K., et al. A second leukotriene B4 receptor, BLT2: A new therapeutic target in inflammation and immunological disorders. J Exp Med 193 421-431 (2000).

Yokomizo, T., Izumi, T., Chang, K., et al. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 387 620-624 (1997).

Wang, S., Gustafson, E., Pang, L., et al. A novel hepatointestinal leukotriene B4 receptor. J Biol Chem 275 40686-40694 (2000).

Size Price Quantity Subtotal
25 µg $112.00 $0.00
50 µg $213.00 $0.00
100 µg $403.00 $0.00
500 µg $1,792.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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