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Leukotriene B4 dimethyl amide

Cayman Chemical Item Number 20115

LTB4 dimethyl amide (CAS 83024-92-4)

Leukotriene B4 dimethyl amide (CAS 83024-92-4)

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Description

LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL.1,2,3 LTB4 dimethyl amide appears to be an antagonist of the LTB4 receptor on guinea pig lung membranes.3

1 Showell, H.J., Otterness, I.G., Marfat, A., et al. Inhibition of leukotriene B4-induced neutrophil degranulation by leukotriene B4-dimethylamide. Biochem Biophys Res Commun 106 741-747 (1982).

2 Shimazaki, T., Kobayashi, Y., Sato, F., et al. Some newly synthesized leukotriene B4 analogs inhibit LTB4-induced lysozyme release from rat polymorphonuclear leukocytes. Prostaglandins 39 459-467 (1990).

3 Falcone, R.C., and Aharony, D. Modulation of ligand binding to leukotriene B4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents. J Pharmacol Exp Ther 255 565-571 (1990).

Synonyms
  • LTB4 dimethyl amide
Formal Name N,​N-​dimethyl-​5S,​12R-​dihydroxy-​6Z,​8E,​10E,​14Z-​eicosatetraenamide
CAS Number 83024-92-4
Molecular Formula C22H37NO3
Formula Weight 363.5
Formulation A solution in methanol
Purity >97%
λmax 270 nm
ε 50
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C[C@@H]​(O)​/C=C/C=C\C=C\[C@@H]​(O)​CCCC(=O)​N(C)​C

Background Reading

Showell, H.J., Otterness, I.G., Marfat, A., et al. Inhibition of leukotriene B4-induced neutrophil degranulation by leukotriene B4-dimethylamide. Biochem Biophys Res Commun 106 741-747 (1982).

Falcone, R.C., and Aharony, D. Modulation of ligand binding to leukotriene B4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents. J Pharmacol Exp Ther 255 565-571 (1990).

Shimazaki, T., Kobayashi, Y., Sato, F., et al. Some newly synthesized leukotriene B4 analogs inhibit LTB4-induced lysozyme release from rat polymorphonuclear leukocytes. Prostaglandins 39 459-467 (1990).

Leukotriene B4 dimethyl amide is available in the following screening library:

Size Price Quantity Subtotal
25 µg $134.00 $0.00
50 µg $255.00 $0.00
100 µg $482.00 $0.00
250 µg $1,072.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Leukotriene B4
LY255283

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