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Leukotriene B₄ dimethyl amide

Cayman Chemical Item Number 20115

LTB₄ dimethyl amide (CAS 83024-92-4)

Leukotriene B4 dimethyl amide (CAS 83024-92-4)

See more	Leukotrienes (90)

Description

LTB₄ dimethyl amide is a moderate inhibitor of LTB₄-induced degranulation of human neutrophils (K_i = 130 nM) and lysozyme release from rat PMNL.^1,2,3 LTB₄ dimethyl amide appears to be an antagonist of the LTB₄ receptor on guinea pig lung membranes.³

1 Showell, H.J., Otterness, I.G., Marfat, A., et al. Inhibition of leukotriene B₄-induced neutrophil degranulation by leukotriene B₄-dimethylamide. Biochem Biophys Res Commun 106 741-747 (1982).

2 Shimazaki, T., Kobayashi, Y., Sato, F., et al. Some newly synthesized leukotriene B₄ analogs inhibit LTB₄-induced lysozyme release from rat polymorphonuclear leukocytes. Prostaglandins 39 459-467 (1990).

3 Falcone, R.C., and Aharony, D. Modulation of ligand binding to leukotriene B₄ receptors on guinea pig lung membranes by sulfhydryl modifying reagents. J Pharmacol Exp Ther 255 565-571 (1990).

Synonyms	LTB4 dimethyl amide
Formal Name	N,N-dimethyl-5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenamide
CAS Number	83024-92-4
Molecular Formula	C₂₂H₃₇NO₃
Formula Weight	363.5
Formulation	A solution in methanol
Purity	>97%
λ_max	270 nm
ε	50
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC/C=C\C[C@@H](O)/C=C/C=C\C=C\[C@@H](O)CCCC(=O)N(C)C

Background Reading

Showell, H.J., Otterness, I.G., Marfat, A., et al. Inhibition of leukotriene B₄-induced neutrophil degranulation by leukotriene B₄-dimethylamide. Biochem Biophys Res Commun 106 741-747 (1982).

Falcone, R.C., and Aharony, D. Modulation of ligand binding to leukotriene B₄ receptors on guinea pig lung membranes by sulfhydryl modifying reagents. J Pharmacol Exp Ther 255 565-571 (1990).

Shimazaki, T., Kobayashi, Y., Sato, F., et al. Some newly synthesized leukotriene B₄ analogs inhibit LTB₄-induced lysozyme release from rat polymorphonuclear leukocytes. Prostaglandins 39 459-467 (1990).

Leukotriene B4 dimethyl amide is available in the following screening library:

Bio-active Lipid II Screening Library (96-Well)

Size	Price	Quantity	Subtotal
25 µg	$134.00		$0.00
50 µg	$255.00		$0.00
100 µg	$482.00		$0.00
250 µg	$1,072.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Leukotriene B₄

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Leukotriene B4 dimethyl amide