See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

12-epi Leukotriene B3

Cayman Chemical Item Number 20134

12-epi LTB3

12-epi Leukotriene B3

See more

Description

12-epi LTB3 is an LTB isomer that would not be formed either by known enzymatic or non-enzymatic processes. The conversion of LTA into different isomers of LTB is complex, and has generated confusion in the past. The enzymatic hydrolysis of LTA leads to LTB, which is the corresponding 5(S),12(R)-dihydroxy acid containing a 6(Z),8(E),10(E) conjugated triene. Non-enzymatic hydrolysis of LTA produces none of this material, but instead produces both the 12(S) and the 12(R) isomers of LTB in which the triene component now contains a 6-trans double bond.1 12-epi (or 12(S)) LTB isomers which contain the natural 6-cis olefin are not produced either by enzymatic or by non-enzymatic processes. Further, 3-series LTs (derived from Mead acid) are only seen in essential fatty acid deficiency. Mead acid is a good substrate for 5-lipoxygenase, leading to LTA3. Enzymatic conversion of LTA3 to LTB3 is very low because LTA3 is actually an inhibitor of LTA hydrolase.2 Non-enzymatic hydrolysis of LTA3 leads to 6-trans-12-epi LTB3, and to 6-trans LTB3. The biological activity of 12-epi LTB3 has not been explored.

1 Sala, A., Bolla, M., Zarini, S., et al. Release of leukotriene A4 versus leukotriene B4 from human polymorphonuclear leukocytes. J Biol Chem 271 17944-17948 (1996).

2 Lefkowith, J.B. Essential fatty acid deficiency: Probing the role of arachidonate in biology. Adv Prostaglandin Thromboxane Leukot Res 20 224-231 (1990).

Synonyms
  • 12-epi LTB3
Formal Name 5S,​12S-​dihydroxy-​6Z,​8E,​10E-​eicosatrienoic acid
Molecular Formula C20H34O4
Formula Weight 338.5
Formulation A solution in ethanol
Purity >97%
λmax 270 nm
ε 50
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CCCCCCCC[C@H]​(O)​/C=C/C=C/C=C\[C@@H]​(O)​CCCC(O)​=O

Background Reading

Sala, A., Bolla, M., Zarini, S., et al. Release of leukotriene A4 versus leukotriene B4 from human polymorphonuclear leukocytes. J Biol Chem 271 17944-17948 (1996).

Lefkowith, J.B. Essential fatty acid deficiency: Probing the role of arachidonate in biology. Adv Prostaglandin Thromboxane Leukot Res 20 224-231 (1990).

12-epi Leukotriene B3 is available in the following screening library:

Size Price Quantity Subtotal
25 µg $289.00 $0.00
50 µg $549.00 $0.00
100 µg $1,040.00 $0.00
250 µg $2,312.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

12-epi Leukotriene B4
Leukotriene A3 methyl ester
Leukotriene B3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?