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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

14,15-dehydro Leukotriene B4

Cayman Chemical Item Number 20150

14,15-dehydro LTB4 (CAS 114616-11-4)

14,15-dehydro Leukotriene B4 (CAS 114616-11-4)

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Description

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway.1,2 It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis.3,4 At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM.5 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM.6

1 Rådmark, O., Malmsten, C., Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B. Biochem Biophys Res Commun 92 954-961 (1980).

2 McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A4. J Biol Chem 260 12832-12837 (1985).

3 Ford-Hutchinson, A.W. Leukotriene B4 in inflammation. Crit Rev Immunol 10 1-12 (1990).

4 McMillan, R.M., and Foster, S.J. Leukotriene B4 and inflammatory disease. Agents Actions 24 114-119 (1988).

5 Wang, S., Gustafson, E., Pang, L., et al. A novel hepatointestinal leukotriene B4 receptor. J Biol Chem 275 40686-40694 (2000).

6 Shimazaki, T., Kobayashi, Y., Sato, F., et al. Some newly synthesized leukotriene B4 analogs inhibit LTB4-induced lysozyme release from rat polymorphonuclear leukocytes. Prostaglandins 39 459-467 (1990).

Synonyms
  • 14,15-dehydro LTB4
Formal Name 5S,​12R-​dihydroxy-​6Z,​8E,​10E-​eicosatrien-​14-​ynoic acid
CAS Number 114616-11-4
Molecular Formula C20H30O4
Formula Weight 334.5
Formulation A solution in ethanol
Purity >97%
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCCCCC[C@@H]​(O)​/C=C/C=C\C=C\[C@@H]​(O)​CCCC(=O)​O

Background Reading

Wang, S., Gustafson, E., Pang, L., et al. A novel hepatointestinal leukotriene B4 receptor. J Biol Chem 275 40686-40694 (2000).

Shimazaki, T., Kobayashi, Y., Sato, F., et al. Some newly synthesized leukotriene B4 analogs inhibit LTB4-induced lysozyme release from rat polymorphonuclear leukocytes. Prostaglandins 39 459-467 (1990).

Rådmark, O., Malmsten, C., Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B. Biochem Biophys Res Commun 92 954-961 (1980).

McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A4. J Biol Chem 260 12832-12837 (1985).

Ford-Hutchinson, A.W. Leukotriene B4 in inflammation. Crit Rev Immunol 10 1-12 (1990).

McMillan, R.M., and Foster, S.J. Leukotriene B4 and inflammatory disease. Agents Actions 24 114-119 (1988).

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Size Price Quantity Subtotal
25 µg $107.00 $0.00
50 µg $203.00 $0.00
100 µg $385.00 $0.00
500 µg $1,712.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-09. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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