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20-carboxy Leukotriene B4

Cayman Chemical Item Number 20180

20-carboxy LTB4 (CAS 80434-82-8)

20-carboxy Leukotriene B4 (CAS 80434-82-8)

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Description

20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. The resulting 20-hydroxy LTB4 is further oxidized to 20-carboxy LTB4.1 LTB4 metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB4 along with other ω-oxidation products.2 The biological activity of 20-carboxy LTB4 is only about 2.6% compared to that of LTB4 in causing PMNL degranulation.3

1 Hansson, G., Lindgren JÅ, Dahlén, S., et al. Identification and biological activity of novel w-oxidized metabolites of leukotriene B4 from human leukocytes. FEBS Lett 130 107-112 (1981).

2 Harper, T.W., Garrity, M.J., and Murphy, R.C. Metabolism of leukotriene B4 in isolated rat hepatocytes. Identification of a novel 18-carboxy-19,20-dinor leukotriene B4 metabolite. J Biol Chem 261 5414-5418 (1986).

3 Feinmark, S.J., Lindgren JÅ, Claesson, H., et al. Stimulation of human leukocyte degranulation by leukotriene B4 and its ω-oxidized metabolites. FEBS Lett 136 141-144 (1981).

Synonyms
  • 20-carboxy LTB4
Formal Name 5S,​12R-​dihydroxy-​6Z,​8E,​10E,​14Z-​eicosatetraene-​1,​20-​dioic acid
CAS Number 80434-82-8
Molecular Formula C20H30O6
Formula Weight 366.5
Formulation A solution in ethanol
Purity >97%
λmax 270 nm
ε 50
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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OC(=O)​CCCC/C=C\C[C@@H]​(O)​/C=C/C=C\C=C\[C@@H]​(O)​CCCC(=O)​O

Background Reading

Powell, W.S. Properties of leukotriene B4 20-hydroxylase from polymorphonuclear leukocytes. J Biol Chem 259 3082-3089 (1984).

Hansson, G., Lindgren JÅ, Dahlén, S., et al. Identification and biological activity of novel w-oxidized metabolites of leukotriene B4 from human leukocytes. FEBS Lett 130 107-112 (1981).

Harper, T.W., Garrity, M.J., and Murphy, R.C. Metabolism of leukotriene B4 in isolated rat hepatocytes. Identification of a novel 18-carboxy-19,20-dinor leukotriene B4 metabolite. J Biol Chem 261 5414-5418 (1986).

Feinmark, S.J., Lindgren JÅ, Claesson, H., et al. Stimulation of human leukocyte degranulation by leukotriene B4 and its ω-oxidized metabolites. FEBS Lett 136 141-144 (1981).

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20-carboxy Leukotriene B4 is available in the following screening library:

Size Price Quantity Subtotal
25 µg $134.00 $0.00
50 µg $255.00 $0.00
100 µg $482.00 $0.00
250 µg $1,072.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Leukotriene B4

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