See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

20-trifluoro Leukotriene B4

Cayman Chemical Item Number 20195

20-trifluoro LTB4 (CAS 115178-97-7)

20-trifluoro Leukotriene B4 (CAS 115178-97-7)

See more

Description

20-trifluoro LTB4 is a synthetic analog of LTB4 resistant to metabolism by ω-oxidation.1 It is equipotent to LTB4 in chemotactic activity with an EC50 of 3 nM.2,3 In contrast to its chemotactic activity, 20-trifluoro LTB4 inhibits LTB4 induced degranulation of neutrophils with an IC50 of 1-2 nM.2,3,1

1 Tanaka, Y., Klauck, T.M., Jubiz, W., et al. Biosynthesis of 20,20,20-trifluoroleukotriene B4 from 20,20,20-trifluoroarachidonic acid: A metabolically stable analog of leukotriene B4 and its application to a study of stimulation of leukotriene B4 synthesis by immunoglobulin G. Arch Biochem Biophys 263 178-190 (1988).

2 Tsai, B.S., Keith, R.H., Villani-Price, D., et al. Differential effects of 20-trifluoromethyl leukotriene B4 on human neutrophil functions. Prostaglandins 37 287-302 (1989).

3 Nilssin, E., Gyllenhammar, H., Lerner, R., et al. The effect of 20-trifluoromethyl leukotriene B4 on neutrophil functional responses. Scand J Immunol 33 357-363 (1991).

Synonyms
  • 20-trifluoro LTB4
Formal Name 5S,​12R-​dihydroxy-​20,​20,​20-​trifluoro-​6Z,​8E,​10E,​14Z-​eicosatetraenoic acid
CAS Number 115178-97-7
Molecular Formula C20H29F3O4
Formula Weight 390.4
Formulation A solution in ethanol
Purity >97%
λmax 270 nm
ε 50
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O[C@@H]​(/C=C/C=C\C=C\[C@@H]​(O)​CCCC(=O)​O)​C/C=C\CCCCC(F)​(F)​F

Background Reading

Nilssin, E., Gyllenhammar, H., Lerner, R., et al. The effect of 20-trifluoromethyl leukotriene B4 on neutrophil functional responses. Scand J Immunol 33 357-363 (1991).

Tsai, B.S., Keith, R.H., Villani-Price, D., et al. Differential effects of 20-trifluoromethyl leukotriene B4 on human neutrophil functions. Prostaglandins 37 287-302 (1989).

Tanaka, Y., Klauck, T.M., Jubiz, W., et al. Biosynthesis of 20,20,20-trifluoroleukotriene B4 from 20,20,20-trifluoroarachidonic acid: A metabolically stable analog of leukotriene B4 and its application to a study of stimulation of leukotriene B4 synthesis by immunoglobulin G. Arch Biochem Biophys 263 178-190 (1988).
Size Price Quantity Subtotal
25 µg $134.00 $0.00
50 µg $255.00 $0.00
100 µg $482.00 $0.00
500 µg $2,144.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Leukotriene B4

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?