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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

11-trans Leukotriene C4

Cayman Chemical Item Number 20230

11-trans LTC4 (CAS 74841-69-3)

11-trans Leukotriene C4 (CAS 74841-69-3)

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Description

11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils1, but not in human neutrophils or RBL-1 cells.2 It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum.3,4 In a radioligand binding assay using guinea pig ileum as a cysteinyl leukotriene receptor preparation, the pKis for LTC4 and 11-trans LTC4 were determined to be 6.42 and 6.58, respectively.4

1 Jörg, A., Henderson, W.R., Murphy, R.C., et al. Leukotriene generation by eosinophils. J Exp Med 155 390-402 (1982).

2 Macchia, L., Hamberg, M., Kumlin, M., et al. Arachidonic acid metabolism in the human mast cell line HMC-1: 5-lipoxygenase gene expression and biosynthesis of thromboxane. Biochim Biophys Acta 1257 58-74 (1995).

3 Dahlén, S., Hedqvist, P., and Hammarström, S. Contractile activities of several cysteine-containing leukotrienes in the guinea-pig lung strip. Eur J Pharmacol 86 207-215 (1983).

4 Sala, A., Civelli, M., Oliva, D., et al. Contractile and binding activities of structural analogues of LTC4 in the longitudinal muscle of guinea-pig ileum. Eicosanoids 3 105-110 (1990).

Synonyms
  • 11-trans LTC4
Formal Name 5S-​hydroxy-​6R-​(S-​glutathionyl)-​7E,​9E,​11E,​14Z-​eicosatetraenoic acid
CAS Number 74841-69-3
Molecular Formula C30H47N3O9S
Formula Weight 625.8
Formulation A solution in ethanol
Purity >97%
λmax 280 nm
ε 40
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C/C=C\C=C/C(CCCCC(=O)​O)​SCC(N)​(C(=O)​NCC(=O)​O)​N1C(=O)​CCC1C(=O)​O

Background Reading

Dahlén, S., Hedqvist, P., and Hammarström, S. Contractile activities of several cysteine-containing leukotrienes in the guinea-pig lung strip. Eur J Pharmacol 86 207-215 (1983).

Jörg, A., Henderson, W.R., Murphy, R.C., et al. Leukotriene generation by eosinophils. J Exp Med 155 390-402 (1982).

Sala, A., Civelli, M., Oliva, D., et al. Contractile and binding activities of structural analogues of LTC4 in the longitudinal muscle of guinea-pig ileum. Eicosanoids 3 105-110 (1990).

Macchia, L., Hamberg, M., Kumlin, M., et al. Arachidonic acid metabolism in the human mast cell line HMC-1: 5-lipoxygenase gene expression and biosynthesis of thromboxane. Biochim Biophys Acta 1257 58-74 (1995).

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Size Price Quantity Subtotal
25 µg $134.00 $0.00
50 µg $255.00 $0.00
100 µg $482.00 $0.00
250 µg $1,072.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Leukotriene C4
Leukotriene C4 methyl ester

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