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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Leukotriene D4

Cayman Chemical Item Number 20310

LTD4 (CAS 73836-78-9)

Leukotriene D4 (CAS 73836-78-9)

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Description

LTD4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.1,2 It is the first cysteinyl-leukotriene metabolite of LTC4. Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.3,4 LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of peripheral airway smooth muscle.5,6

1 Örning, L., Hammarström, S., and Samuelsson, B. Leukotriene D: A slow reacting substance from rat basophilic leukemia cells. Proc Natl Acad Sci USA 77 2014-2017 (1980).

2 Hammarström, S., Örning, L., and Bernström, K. Metabolism of leukotrienes. Mol Cell Biochem 69 7-16 (1985).

3 Hedqvist, P., Dahlén, S., Gustafsson, L., et al. Biological profile of leukotrienes C4 and D4. Acta Physiol Scand 110 331-333 (1980).

4 Samuelsson, B., Dahlén, S., Lindgren JÅ, et al. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 237 1171-1176 (1987).

5 Lefer, A.M. Leukotrienes as mediators of ischemia and shock. Biochem Pharmacol 35 123-127 (1986).

6 Drazen, J.M., Austen, K.F., Lewis, R.A., et al. Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. Proc Natl Acad Sci USA 77 4354-4358 (1980).

Synonyms
  • LTD4
Formal Name 5S-​hydroxy-​6R-​(S-​cysteinylglycinyl)-​7E,​9E,​11Z,​14Z-​eicosatetraenoic acid
CAS Number 73836-78-9
Molecular Formula C25H40N2O6S
Formula Weight 496.7
Formulation A solution in ethanol
Purity >97%
λmax 280 nm
ε 40
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C\C=C/C=C\C=C/C(SCC(N)​C(=O)​NCC(=O)​O)​[C@@H]​(O)​CCCC(=O)​O

Background Reading

Drazen, J.M., Austen, K.F., Lewis, R.A., et al. Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. Proc Natl Acad Sci USA 77 4354-4358 (1980).

Hedqvist, P., Dahlén, S., Gustafsson, L., et al. Biological profile of leukotrienes C4 and D4. Acta Physiol Scand 110 331-333 (1980).

Hammarström, S., Örning, L., and Bernström, K. Metabolism of leukotrienes. Mol Cell Biochem 69 7-16 (1985).

Lefer, A.M. Leukotrienes as mediators of ischemia and shock. Biochem Pharmacol 35 123-127 (1986).

Örning, L., Hammarström, S., and Samuelsson, B. Leukotriene D: A slow reacting substance from rat basophilic leukemia cells. Proc Natl Acad Sci USA 77 2014-2017 (1980).

Samuelsson, B., Dahlén, S., Lindgren JÅ, et al. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 237 1171-1176 (1987).

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Size Price Quantity Subtotal
25 µg $104.00 $0.00
50 µg $198.00 $0.00
100 µg $374.00 $0.00
1 mg $2,912.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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