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11-trans Leukotriene D4

Cayman Chemical Item Number 20330

11-trans LTD4 (CAS 79768-40-4)

11-trans Leukotriene D4 (CAS 79768-40-4)

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Description

11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4.1,2 It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.2,3

1 Baker, S.R., Boot, J.R., Jamieson, W.B., et al. The comparative in vitro pharmacology of leukotriene D4 and its isomers. Biochem Biophys Res Commun 103(4) 1258-1264 (1981).

2 Tsai, B.S., Bernstein, P., Macia, R.A., et al. Comparative potency and pharmacology of isomers of leukotriene D4 on guinea-pig trachea: Requirement for a 5(S)6(R) configuration. Prostaglandins 23(4) 489-506 (1982).

3 Krell, R.D., Osborn, R., Falcone, K., et al. Contraction of isolated airway smooth muscle by synthetic leukotrienes C4 and D4. Prostaglandins 22(3) 387-409 (1981).

Synonyms
  • 11-trans LTD4
Formal Name 5S-​hydroxy-​6R-​(S-​cysteinylglycinyl)-​7E,​9E,​11E,​14Z-​eicosatetraenoic acid
CAS Number 79768-40-4
Molecular Formula C25H40N2O6S
Formula Weight 496.7
Formulation A solution in ethanol
Purity >97%
λmax 278 nm
ε 40
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C/C=C\C=C/C(SCC(N)​C(=O)​NCC(=O)​O)​[C@@H]​(O)​CCCC(=O)​O

Background Reading

Krell, R.D., Osborn, R., Falcone, K., et al. Contraction of isolated airway smooth muscle by synthetic leukotrienes C4 and D4. Prostaglandins 22(3) 387-409 (1981).

Baker, S.R., Boot, J.R., Jamieson, W.B., et al. The comparative in vitro pharmacology of leukotriene D4 and its isomers. Biochem Biophys Res Commun 103(4) 1258-1264 (1981).

Tsai, B.S., Bernstein, P., Macia, R.A., et al. Comparative potency and pharmacology of isomers of leukotriene D4 on guinea-pig trachea: Requirement for a 5(S)6(R) configuration. Prostaglandins 23(4) 489-506 (1982).

Size Price Quantity Subtotal
25 µg $134.00 $0.00
50 µg $255.00 $0.00
100 µg $482.00 $0.00
250 µg $1,072.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Leukotriene D4
Leukotriene D4-d5
Leukotriene D4 methyl ester

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