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Leukotriene E4

Cayman Chemical Item Number 20410

LTE4 (CAS 75715-89-8)

Leukotriene E4 (CAS 75715-89-8)

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Description

Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone.1 It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).2 LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of cysteinyl leukotrienes.1,3 Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is often used as an indicator of asthma.4,5,6 In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.5

1 Bernström, K., and Hammarström, S. Metabolism of leukotriene D by porcine kidney. J Biol Chem 256 9579-9582 (1981).

2 Samuelsson, B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science 220 568-575 (1983).

3 Lefer, A.M. Leukotrienes as mediators of ischemia and shock. Biochem Pharmacol 35 123-127 (1986).

4 Kumlin, M., Stensvad, F., Larsson, L., et al. Validation and application of a new simple strategy for measurements of urinary leukotriene E4 in humans. Clin Exp Allergy 25 467-479 (1995).

5 Drazen, J.M., O'Brien, J., Sparrow, D., et al. Recovery of leukotriene E4 from the urine of patients with airway obstruction. Am Rev Respir Dis 146 104-108 (1992).

6 Kumlin, M., Dahlén, B., Björck, T., et al. Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics. Am Rev Respir Dis 146 96-103 (1992).

Synonyms
  • LTE4
Formal Name 5S-​hydroxy-​6R-​(S-​cysteinyl)-​7E,​9E,​11Z,​14Z-​eicosatetraenoic acid
CAS Number 75715-89-8
Molecular Formula C23H37NO5S
Formula Weight 439.6
Formulation A solution in ethanol
Purity >97%
λmax 281 nm
ε 40
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C\C=C/C=C\C=C/C(SCC(N)​C(=O)​O)​[C@@H]​(O)​CCCC(=O)​O

Background Reading

Samuelsson, B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science 220 568-575 (1983).

Kumlin, M., Dahlén, B., Björck, T., et al. Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics. Am Rev Respir Dis 146 96-103 (1992).

Bernström, K., and Hammarström, S. Metabolism of leukotriene D by porcine kidney. J Biol Chem 256 9579-9582 (1981).

Kumlin, M., Stensvad, F., Larsson, L., et al. Validation and application of a new simple strategy for measurements of urinary leukotriene E4 in humans. Clin Exp Allergy 25 467-479 (1995).

Lefer, A.M. Leukotrienes as mediators of ischemia and shock. Biochem Pharmacol 35 123-127 (1986).

Drazen, J.M., O'Brien, J., Sparrow, D., et al. Recovery of leukotriene E4 from the urine of patients with airway obstruction. Am Rev Respir Dis 146 104-108 (1992).

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Size Price Quantity Subtotal
25 µg $58.00 $0.00
50 µg $110.00 $0.00
100 µg $209.00 $0.00
1 mg $1,624.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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N-acetyl Leukotriene E4
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