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N-acetyl Leukotriene E4

Cayman Chemical Item Number 20420

N-acetyl LTE4 (CAS 80115-95-3)

N-acetyl Leukotriene E4 (CAS 80115-95-3)

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Description

N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. This route of metabolism is prominent in the rat, but of minor importance in humans.1,2 N-acetyl LTE4 is 100 times less potent than LTC4 as a vasoconstricting agent.2 In healthy human subjects urinary excretion of N-acetyl LTE4 is about 1.5 nmol/mol creatinine, which is considerably less than that of LTE4 (12 nmol/mol creatinine).3

1 Denzlinger, C., Rapp, S., Hagmann, W., et al. Leukotrienes as mediators in tissue trauma. Science 230 330-332 (1985).

2 Foster, A., Fitzsimmons, B., and Letts, L.G. The synthesis of N-acetyl-leukotriene E4 and its effects on cardiovascular and respiratory function of the anesthetized pig. Prostaglandins 31 1077-1086 (1986).

3 Huber, M., Müller, J., Leier, I., et al. Metabolism of cysteinyl leukotrienes in monkey and man. Eur J Biochem 194 309-315 (1990).

Synonyms
  • N-acetyl LTE4
Formal Name 5S-​hydroxy-​6R-​(S-​(N-​acetyl)cysteinyl)-​7E,​9E,​11Z,​14Z-​eicosatetraenoic acid
CAS Number 80115-95-3
Molecular Formula C25H39NO6S
Formula Weight 481.6
Formulation A solution in ethanol
Purity >97%
λmax 281 nm
ε 40
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C\C=C/C=C\C=C/C(SCC(NC(=O)​C)​C(=O)​O)​[C@@H]​(O)​CCCC(=O)​O

Background Reading

Huber, M., Müller, J., Leier, I., et al. Metabolism of cysteinyl leukotrienes in monkey and man. Eur J Biochem 194 309-315 (1990).

Foster, A., Fitzsimmons, B., and Letts, L.G. The synthesis of N-acetyl-leukotriene E4 and its effects on cardiovascular and respiratory function of the anesthetized pig. Prostaglandins 31 1077-1086 (1986).

Hammarström, S., Örning, L., and Bernström, K. Metabolism of leukotrienes. Mol Cell Biochem 69 7-16 (1985).

Denzlinger, C., Rapp, S., Hagmann, W., et al. Leukotrienes as mediators in tissue trauma. Science 230 330-332 (1985).

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Size Price Quantity Subtotal
25 µg $86.00 $0.00
50 µg $163.00 $0.00
100 µg $310.00 $0.00
250 µg $688.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Leukotriene C4
Leukotriene E4

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