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Leukotriene F4

Cayman Chemical Item Number 20520

LTF₄ (CAS 83851-42-7)

Leukotriene F4 (CAS 83851-42-7)

See more	Leukotrienes (90)

Description

LTF₄ is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE₄ with γ-glutamyl transpeptidase and glutathione. LTF₄ is a weak agonist in its ability to contract vascular smooth muscle.¹ The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD₄ > LTC₄ > LTE₄ >> LTF₄.^1,2

1 Bernstrom, K., and Hammarström, S. A novel leukotriene formed by transpeptidation of leukotriene E₄. Biochem Biophys Res Commun 109 800-804 (1982).

2 Lord, A., Charleson, S., and Letts, L.G. Leukotriene F4 and the release of arachidonic acid metabolites from perfused guinea pig lungs in vitro. Prostaglandins 29 651-660 (1985).

Synonyms	LTF4
Formal Name	5S-hydroxy-6R-(S-γ-glutamylcysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid
CAS Number	83851-42-7
Molecular Formula	C₂₈H₄₄N₂O₈S
Formula Weight	568.7
Formulation	A solution in methanol
Purity	>97%
λ_max	280 nm
ε	40
Stability	1 year
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SCC(NC(CCC(C(O)=O)N)=O)C(O)=O)[C@H](O)CCCC(O)=O

Background Reading

Bernstrom, K., and Hammarström, S. A novel leukotriene formed by transpeptidation of leukotriene E₄. Biochem Biophys Res Commun 109 800-804 (1982).

Lord, A., Charleson, S., and Letts, L.G. Leukotriene F4 and the release of arachidonic acid metabolites from perfused guinea pig lungs in vitro. Prostaglandins 29 651-660 (1985).

Leukotriene F4 is available in the following screening library:

Bio-active Lipid II Screening Library (96-Well)

Size	Price	Quantity	Subtotal
25 µg	$103.00		$0.00
50 µg	$196.00		$0.00
100 µg	$371.00		$0.00
250 µg	$824.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Leukotriene C₄

Leukotriene D₄

Leukotriene E₄

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