CB1 Receptor Blocking Peptide

CB₁ Receptor Blocking Peptide

Cayman Chemical Item Number 301500

Cannabinoid Receptor 1

Description

Peptide sequence: human, rat, and murine CB₁ receptor sequence amino acids 1-14 (MKSILDGLADTTFR) · To be used in conjunction with Cayman’s CB₁ receptor polyclonal antibody (Catalog No. 101500) to block protein-antibody complex formation during analysis for the CB₁ receptor. · The CB₁ receptor and the splice variant CB1a are localized mainly in the brain.^1,2,3

1 Matsuda, L.A., Lolait, S.J., Brownstein, M.J., et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346 561-564 (1990).

2 Shire, D., Carillon, C., Kaghad, M., et al. An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. J Biol Chem 270 3726-3731 (1995).

3 Munro, S., Thomas, K.L., and Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365 61-65 (1993).

Synonyms

Cannabinoid Receptor 1

Formulation

200 μg peptide in 200 µl TBS, pH 7.4, containing 0.02% sodium azide

Stability

2 years

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Background Reading

Matsuda, L.A., Lolait, S.J., Brownstein, M.J., et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346 561-564 (1990).

Shire, D., Carillon, C., Kaghad, M., et al. An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. J Biol Chem 270 3726-3731 (1995).

Howlett, A.C., Song, C., Berglund, B.A., et al. Characterization of CB₁ cannabinoid receptors using receptor peptide fragments and site-directed antibodies. Mol Pharmacol 53 504-510 (1998).

McIntosh, H.H., Song, C., and Howlett, A.C. CB₁ cannabinoid receptor: Cellular regulation and distribution in N18TG2 neuroblastoma cells. Mol Brain Res 53 163-173 (1998).

Munro, S., Thomas, K.L., and Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365 61-65 (1993).

Gérard, C.M., Mollereau, C., Vassart, G., et al. Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem J 279 129-134 (1991).

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200 µg

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