CB1 Receptor Blocking Peptide
Cayman Chemical Item Number 301500
Cannabinoid Receptor 1
Description
Peptide sequence:
human, rat, and murine CB1 receptor sequence amino acids 1-14 (MKSILDGLADTTFR)
·
To be used in conjunction with Cayman’s CB1 receptor polyclonal antibody (Catalog No. 101500) to block protein-antibody complex formation during analysis for the CB1 receptor. · The CB1 receptor and the splice variant CB1a are localized mainly in the brain.1,2,3
1
Matsuda, L.A., Lolait, S.J., Brownstein, M.J., et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346 561-564 (1990).
2
Shire, D., Carillon, C., Kaghad, M., et al. An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. J Biol Chem 270 3726-3731 (1995).
3
Munro, S., Thomas, K.L., and Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365 61-65 (1993).
| Synonyms |
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| Formulation |
200 μg peptide in 200 µl TBS, pH 7.4, containing 0.02% sodium azide |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
Background Reading
Matsuda, L.A., Lolait, S.J., Brownstein, M.J., et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346 561-564 (1990).
Shire, D., Carillon, C., Kaghad, M., et al. An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. J Biol Chem 270 3726-3731 (1995).
Howlett, A.C., Song, C., Berglund, B.A., et al. Characterization of CB1 cannabinoid receptors using receptor peptide fragments and site-directed antibodies. Mol Pharmacol 53 504-510 (1998).
McIntosh, H.H., Song, C., and Howlett, A.C. CB1 cannabinoid receptor: Cellular regulation and distribution in N18TG2 neuroblastoma cells. Mol Brain Res 53 163-173 (1998).
Munro, S., Thomas, K.L., and Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365 61-65 (1993).
Gérard, C.M., Mollereau, C., Vassart, G., et al. Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem J 279 129-134 (1991).
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Pricing updated 2012-02-12.
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