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Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

PPARα Blocking Peptide

Cayman Chemical Item Number 301710

Peroxisome Proliferator-activated Receptor α

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Description

Each vial contains 200 µg of lyophilized peptide derived from the human/mouse/rat PPARα sequence (amino acids 22-36; PLSEEFLQEMGNIQE).1 This peptide was used as an antigen for production of Cayman’s PPARα polyclonal antibody (Catalog No. 101710) and can be used in conjunction with this antibody to block protein-antibody complex formation during immunohistochemical analysis for this protein.

1 Mukherjee, R., Jow, L., Noonan, D., et al. Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J Steroid Biochem Mol Biol 51 157-166 (1994).

Synonyms
  • Peroxisome Proliferator-activated Receptor α
Formulation A lyophilized peptide
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Devchand, P.R., Keller, H., Peters, J.M., et al. The PPARα-leukotriene B4 pathway to inflammation control. Nature 384 39-43 (1996).

Kroetz, D.L., Yook, P., Costet, P., et al. Peroxisome proliferator-activated receptor α controls the hepatic CYP4A induction adaptive response to starvation and diabetes. J Biol Chem 273 31581-31589 (1998).

Forman, B.M., Chen, J., and Evans, R.M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc Natl Acad Sci USA 94 4312-4317 (1997).

Sher, T., Yi, H., McBride, O.W., et al. cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 32 5598-5604 (1993).

Gearing, K.L., Crickmore, A., and Gustafsson, J. Structure of the mouse peroxisome proliferator activated receptor a gene. Biochem Biophys Res Commun 199 255-263 (1994).

Latruffe, N., and Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie 79 81-94 (1997).

Martin, G., Schoonjans, K., Lefevbre, A., et al. Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARα and PPARγ activators. J Biol Chem 272 28210-28217 (1997).

Lehmann, J.M., Lenhard, J.M., Oliver, B.B., et al. Peroxisome proliferator-activated receptors a and g are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272 3406-3410 (1997).

Mukherjee, R., Jow, L., Noonan, D., et al. Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J Steroid Biochem Mol Biol 51 157-166 (1994).

Lemberger, T., Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 12 335-363 (1996).

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1 ea $107.00 $0.00
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This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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