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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

EP2 Receptor Blocking Peptide

Cayman Chemical Item Number 301750

Prostaglandin E2 Receptor 2; PGE2 Receptor 2

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Description

Each vial contains 200 µg of lyophilized peptide derived from the human EP2 receptor sequence (C-terminal amino acids 335-358; SLRTQDATQTSCSTQSDASKQADL).1 This peptide was used as an antigen for production of the EP2 receptor polyclonal antibody (Catalog No. 101750) and can be used in conjunction with this antibody to block protein-antibody complex formation during immunochemical analysis for the EP2 receptor. The biological effects of prostaglandin E2 (PGE2) are mediated through interaction with four distinct membrane-bound G-protein coupled EP receptors: EP1, EP2, EP3, and EP4.2,3 Binding of PGE2 to the EP2 receptor results in an increase in adenylate cyclase activity with a subsequent increase in cAMP.1,4 Pharmacologically, EP2 receptors mediate relaxation of smooth muscle and are distinguished from EP4 receptors by their sensitivity to the EP2 receptor selective agonist butaprost.2,3,1 The human EP2 receptor is comprised of 358 amino acids with a molecular mass of approximately 40,000.1 A band at 53 kDa is detected in most samples by western blotting. mRNA for the EP2 receptor is expressed in a variety of tissues including lung, placenta, spleen, intestine, kidney, and sensory neuron.1,4,5

1 Regan, J.W., Bailey, T.J., Pepperl, D.J., et al. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Mol Pharmacol 46 213-220 (1994).

2 Coleman, R.A., Smith, W.L., and Narumiya, S. Classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 46 205-229 (1994).

3 Coleman, R.A., Dahlén, S., Drazen, J.M., et al. Classification of leukotriene receptors IUPHAR receptor compendium. IUPHAR Compendium 1-7 (1997).

4 Nemoto, K., Pilbeam, C.C., Bilak, S.R., et al. Molecular cloning and expression of a rat prostaglandin E2 receptor of the EP2 subtype. Prostaglandins 54 713-725 (1997).

5 Southall, M.D., and Vasko, M.R. Prostaglandin receptor subtypes, EP3C and EP4, mediate the prostaglandin E2-induced cAMP production and sensitization of sensory neurons. J Biol Chem 276(19) 16083-16091 (2001).

Synonyms
  • Prostaglandin E2 Receptor 2
  • PGE2 Receptor 2
Formulation A lyophilized peptide
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Coleman, R.A., Smith, W.L., and Narumiya, S. Classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 46 205-229 (1994).

Southall, M.D., and Vasko, M.R. Prostaglandin receptor subtypes, EP3C and EP4, mediate the prostaglandin E2-induced cAMP production and sensitization of sensory neurons. J Biol Chem 276(19) 16083-16091 (2001).

Regan, J.W., Bailey, T.J., Pepperl, D.J., et al. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Mol Pharmacol 46 213-220 (1994).

Coleman, R.A., Eglen, R.M., Jones, R.L., et al. Classification of prostanoid receptors IUPHAR receptor compendium. IUPHAR Compendium 1-12 (1997).

Nemoto, K., Pilbeam, C.C., Bilak, S.R., et al. Molecular cloning and expression of a rat prostaglandin E2 receptor of the EP2 subtype. Prostaglandins 54 713-725 (1997).

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Size Price Quantity Subtotal
200 µg $107.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

EP2 Receptor Polyclonal Antibody
EP2 Receptor Polyclonal PE Antibody

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