316810  Bimatoprost (free acid)-d4

17-phenyl trinor Prostaglandin F2α-d4

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• See more Mass Spectrometry; Prostaglandins

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Bimatoprost (free acid)-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of bimatoprost (free acid) by GC- or LC-mass spectrometry. Bimatoprost (free acid) is a metabolically stable analog of prostaglandin F2α (PGF2α) and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α.1 At the rat recombinant FP receptor expressed in CHO cells bimatoprost (free acid) inhibits PGF2α binding with a Ki of 1.1 nM.2 The isopropyl ester of bimatoprost (free acid)-d4 is slightly better than PGF2α isopropyl ester in reducing the intraocular pressure in the cat eye without any irritation.3
1  Balapure, A.K., Rexroad, C.E., Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor. Biochem Pharmacol 38 2375-2381 (1989).
2  Lake, S., Gullberg, H., Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor. FEBS Lett 355 317-325 (1994).
3  Stjernschantz, J., Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs of the Future 17 691-704 (1992).


Purchase 316810 Bimatoprost (free acid)-d4

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-18.
Prices are subject to change without notice.

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