See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Latanoprost (free acid)-d4

Cayman Chemical Item Number 316811

PhXA 85-d4; 17-phenyl-13,14-dihydro trinor Prostaglandin F2α-d4; Lat-FA-d4

Latanoprost (free acid)-d4

See more

Description

Latanoprost (free acid)-d4 (Lat-FA-d4) contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of Lat-FA by GC- or LC-mass spectrometry. Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.1 It is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. As an isopropyl ester, latanoprost acts as a prodrug which is converted to Lat-FA by endogenous esterase enzymes. Lat-FA is a potent FP receptor agonist with an EC50 value of 3.6 nM for human FP receptors, which is twice the potency of PGF2α and more than 200 times more potent latanoprost.2 The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid.3 However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.4

1 Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs Future 17 691-704 (1992).

2 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

3 Camras, C.B., Alm, A., Watson, P., et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Ophthalmology 103 1916-1924 (1996).

4 Sugamoto, K., Matsushita, Y., and Matsui, T. Facile and general method for preparation of (E)-4-hydroxy-2-alkenals. Lipids 32 903-905 (1997).

Synonyms
  • PhXA 85-d4
  • 17-phenyl-13,14-dihydro trinor Prostaglandin F2α-d4
  • Lat-FA-d4
Formal Name 9α,​11α,​15R-​trihydroxy-​17-​phenyl-​18,​19,​20-​trinor-​prost-​5Z-​en-​1-​oic-​3,​3,​4,​4-​d4 acid
Molecular Formula C23H30D4O5
Formula Weight 394.5
Formulation A solution in methyl acetate
Purity ≥99% deuterated product
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
OC(CCc1ccccc1)​CC[C@H]​1C(O)​CC(O)​C1C/C=C\CCCC(=O)​O

Background Reading

Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs Future 17 691-704 (1992).

Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

Sugamoto, K., Matsushita, Y., and Matsui, T. Facile and general method for preparation of (E)-4-hydroxy-2-alkenals. Lipids 32 903-905 (1997).

Camras, C.B., Alm, A., Watson, P., et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Ophthalmology 103 1916-1924 (1996).

Show all 4 Hide all but first 3
Size Price Quantity Subtotal
50 µg $29.00 $0.00
100 µg $55.00 $0.00
500 µg $232.00 $0.00
5 mg $1,740.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

15-keto Latanoprost
15-keto Latanoprost (free acid)
17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide
5-trans Latanoprost
Latanoprost
Latanoprost-d4
Latanoprost EIA Kit
Latanoprost (free acid)
Show all 8 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?