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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Leukotriene B4-d4

Cayman Chemical Item Number 320110

LTB4-d4

Leukotriene B4-d4

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Description

Leukotriene B4-d4 (LTB4-d4) contains four deuterium atoms at the 6, 7, 14, and 15 positions. It is intended for use as an internal standard for the quantification of LTB4 by GC- or LC-mass spectrometry. LTB4 is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway.1,2,3 It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10−10 M), LTB4 causes chemotaxis and chemokinesis in human PMNL.4 At higher concentrations, (1.0 x 10−7 M), LTB4 leads to neutrophil aggregation and degranulation as well as superoxide anion production.4,5

1 Rådmark, O., Malmsten, C., Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B. Biochem Biophys Res Commun 92 954-961 (1980).

2 Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., et al. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286 264-265 (1980).

3 McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A4. J Biol Chem 260 12832-12837 (1985).

4 Ford-Hutchinson, A.W. Leukotriene B4 in inflammation. Crit Rev Immunol 10 1-12 (1990).

5 McMillan, R.M., and Foster, S.J. Leukotriene B4 and inflammatory disease. Agents Actions 24 114-119 (1988).

Synonyms
  • LTB4-d4
Formal Name 5S,​12R-​dihydroxy-​6Z,​8E,​10E,​14Z-​eicosatetraenoic-​6,​7,​14,​15-​d4 acid
Molecular Formula C20H28D4O4
Formula Weight 340.5
Formulation A solution in acetonitrile
Purity ≥99% deuterated product
λmax 270 nm
ε 50
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C[C@@H]​(O)​/C=C/C=C\C=C\[C@@H]​(O)​CCCC(=O)​O

Background Reading

McMillan, R.M., and Foster, S.J. Leukotriene B4 and inflammatory disease. Agents Actions 24 114-119 (1988).

McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A4. J Biol Chem 260 12832-12837 (1985).

Rådmark, O., Malmsten, C., Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B. Biochem Biophys Res Commun 92 954-961 (1980).

Ford-Hutchinson, A.W. Leukotriene B4 in inflammation. Crit Rev Immunol 10 1-12 (1990).

Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., et al. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286 264-265 (1980).

Show all 5 Hide all but first 3
Size Price Quantity Subtotal
25 µg $256.00 $0.00
50 µg $486.00 $0.00
100 µg $922.00 $0.00
500 µg $4,096.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

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Leukotriene B4

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