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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CysLT1 Receptor Blocking Peptide

Cayman Chemical Item Number 320500

Cysteinyl Leukotriene Receptor 1

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Description

Peptide sequence: human CysLT1 receptor amino acids 318-337 (TYVPRKKASLPEKGEEICKV) · To be used in conjunction with Cayman’s CysLT1 receptor polyclonal antibody (Catalog No. 120500) to block protein-antibody complex formation during analysis for the CysLT1 receptor. · Each vial contains 200 µg of lyophilized peptide derived from the human CysLT1 protein sequence. The cysteinyl leukotrienes (LTC4, LTD4, and LTE4) contract airway and pulmonary vascular smooth muscle, increase vascular permeability and stimulate mucus secretion, thereby playing a major role in asthma.1,2,3,4 LTC4, LTD4, and LTE4 mediate their actions via at least 2 receptors designated CysLT1 and CysLT2.1 Cloning of the human CysLT1 receptor reveals it is a 337 amino acid protein with a calculated molecular mass of 38,549.5 The rank order of binding for leukotrienes to the cloned receptor, as determined using a radioligand binding assay, is LTD4 >> LTC4 = LTE4 >> LTB4.5 The mRNA for the human CysLT1 receptor is expressed in spleen and peripheral blood leukocytes with smaller amounts in lung, placenta, and small intestine.

1 Gorenne, I., Norel, X., and Brink, C. Cysteinyl leukotriene receptors in the human lung: What’s new? Trends Pharmacol Sci 17 342-343 (1996).

2 Dahlén, S., Hansson, G., Hedqvist, P., et al. Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4. Proc Natl Acad Sci USA 80 1712-1716 (1983).

3 Busse, W.W. The role of leukotrienes in asthma and allergic rhinitis. Clin Exp Allergy 26 868-879 (1996).

4 Hedqvist, P., Dahlén, S., Gustafsson, L., et al. Biological profile of leukotrienes C4 and D4. Acta Physiol Scand 110 331-333 (1980).

5 Lynch, K.R., O'Neill, G.P., Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399 789-793 (1999).

Synonyms
  • Cysteinyl Leukotriene Receptor 1
Formulation A lyophilized peptide
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Dahlén, S., Hansson, G., Hedqvist, P., et al. Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4. Proc Natl Acad Sci USA 80 1712-1716 (1983).

Busse, W.W. The role of leukotrienes in asthma and allergic rhinitis. Clin Exp Allergy 26 868-879 (1996).

Gorenne, I., Norel, X., and Brink, C. Cysteinyl leukotriene receptors in the human lung: What’s new? Trends Pharmacol Sci 17 342-343 (1996).

Lynch, K.R., O'Neill, G.P., Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399 789-793 (1999).

Hedqvist, P., Dahlén, S., Gustafsson, L., et al. Biological profile of leukotrienes C4 and D4. Acta Physiol Scand 110 331-333 (1980).

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Size Price Quantity Subtotal
200 µg $107.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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