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12(R)-HEPE

Cayman Chemical Item Number 32545

(CAS 109430-12-8)

12(R)-HEPE (CAS 109430-12-8)

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Description

12(R)-HEPE is a monohydroxy fatty acid synthesized from EPA by the eggs of the sea urchin, S. purpuratus.1 The biological activity of 12(R)-HEPE has not been extensively documented, but may be similar to that of 12(R)-HETE (Catalog No. 34560).2,3

1 Hawkins, D.J., and Brash, A.R. Eggs of the sea urchin, Strongylocentrotus purpuratus, contain a prominent (11R) and (12R) lipoxygenase activity. J Biol Chem 262 7629-7634 (1987).

2 Masferrer, J.L., Dunn, M.W., and Schwartzman, M.L. 12(R)-Hydroxyeicosatetraenoic acid, an endogenous corneal arachidonate metabolite, lowers intraocular pressure in rabbits. Invest Ophthamol Vis Sci 31 535-539 (1990).

3 Conners, M.S., Schwartzman, M.L., Quan, X., et al. Enhancement of delayed hypersensitivity inflammatory reactions in guinea pig skin by 12(R)-hydroxy-5,8,14-eicosatrienoic acid. J Invest Dermatol 104 47-51 (1995).

Formal Name 12R-​hydroxy-​5Z,​8Z,​10E,​14Z,​17Z-​eicosapentaenoic acid
CAS Number 109430-12-8
Molecular Formula C20H30O3
Formula Weight 318.5
Formulation A solution in ethanol
Purity ≥98%
λmax 237 nm
ε 23
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CC/C=C\C/C=C\C[C@@H]​(O)​\C=C\C=C\C/C=C\CCCC(=O)​O

Background Reading

Masferrer, J.L., Dunn, M.W., and Schwartzman, M.L. 12(R)-Hydroxyeicosatetraenoic acid, an endogenous corneal arachidonate metabolite, lowers intraocular pressure in rabbits. Invest Ophthamol Vis Sci 31 535-539 (1990).

Conners, M.S., Schwartzman, M.L., Quan, X., et al. Enhancement of delayed hypersensitivity inflammatory reactions in guinea pig skin by 12(R)-hydroxy-5,8,14-eicosatrienoic acid. J Invest Dermatol 104 47-51 (1995).

Hawkins, D.J., and Brash, A.R. Eggs of the sea urchin, Strongylocentrotus purpuratus, contain a prominent (11R) and (12R) lipoxygenase activity. J Biol Chem 262 7629-7634 (1987).

12(R)-HEPE is available in the following screening library:

Size Price Quantity Subtotal
25 µg $124.00 $0.00
50 µg $236.00 $0.00
100 µg $446.00 $0.00
250 µg $992.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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HEPES Stock Solution (1 M)
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