Cayman Chemical | 4-hydroxy Nonenal-d3 | Description • 4-HNE-d3

332101 4-hydroxy Nonenal-d3

4-HNE-d3

Click image to enlarge

• See below for pricing and ordering

• See analysis tools

• See more Mass Spectrometry; Oxylipins; Oxidative Injury

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

4-hydroxy Nonenal-d3 (4-HNF-d3) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-HNE by GC- or LC-mass spectrometry. 4-HNE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid.^1,2 4-HNE is widely used as a marker of lipid peroxidation.² It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity.^1,2,3 4-HNE inhibits pro-oxidant-induced Ca2+ release from mitochondria at 10-50 µM.²

1 Pryor, W.A., Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Radic Biol Med 8 541-543 (1990).

2 Esterbauer, H., Schaur, R.J., Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes. Free Radic Biol Med 11 81-128 (1991).

3 Sodum, R.S., Chung, F. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal. Cancer Res 48 320-323 (1988).

	Download Product Insert 143 Kb PDF
	Download Material Safety Data Sheet (MSDS) 17 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm

Purchase 332101 4-hydroxy Nonenal-d3

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-16.
Prices are subject to change without notice.