4-hydroxy Nonenal-d3

4-hydroxy Nonenal-d₃

Cayman Chemical Item Number 332101

4-HNE-d₃

Description

4-hydroxy Nonenal-d₃ (4-HNF-d₃) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-HNE by GC- or LC-mass spectrometry. 4-HNE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid.^1,2 4-HNE is widely used as a marker of lipid peroxidation.² It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity.^1,2,3 4-HNE inhibits pro-oxidant-induced Ca2+ release from mitochondria at 10-50 µM.²

1 Pryor, W.A., and Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Radic Biol Med 8 541-543 (1990).

2 Esterbauer, H., Schaur, R.J., and Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes. Free Radic Biol Med 11 81-128 (1991).

3 Sodum, R.S., and Chung, F. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal. Cancer Res 48 320-323 (1988).

Synonyms

4-HNE-d3

Formal Name

(±)-4-hydroxy-9,9,9-d3-non-2E-enal

Molecular Formula

C₉H₁₃D₃O₂

Formula Weight

159.2

Formulation

A solution in methyl acetate

Purity

≥99% deuterated product

Stability

6 months

Storage

-80°C

Shipping

Dry ice in continental US; may vary elsewhere

SMILES

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CCCCCC(O)\C=C\C=O

Background Reading

Pryor, W.A., and Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Radic Biol Med 8 541-543 (1990).

Esterbauer, H., Schaur, R.J., and Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes. Free Radic Biol Med 11 81-128 (1991).

Sodum, R.S., and Chung, F. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal. Cancer Res 48 320-323 (1988).

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Subtotal

50 µg 
$42.00

$0.00

100 µg 
$80.00

$0.00

500 µg 
$336.00

$0.00

1 mg 
$588.00

$0.00

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4-hydroxy Nonenal-d₃