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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

15(S)-HETE-d8

Cayman Chemical Item Number 334720

(CAS 84807-87-4)

15(S)-HETE-d8 (CAS 84807-87-4)

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Description

15(S)-HETE-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of 15(S)-HETE by GC- or LC-MS. 15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes.1 15(S)-HETE is present in µg/ml concentrations in the nasal secretions of allergic rhinitis.2

1 Nadel, J.A., Conrad, D.J., Ueki, I.F., et al. Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocyes, leukocytes, and airway cells. J Clin Invest 87 1139-1145 (1991).

2 Ramis, I., Roselló-Catafau, J., Bulbena, O., et al. 15-Hydroxyeicosatetraenoic acid as a major eicosanoid in nasal secretions: Assay by high-performance liquid chromatographic-radioimmunoassay and gas chromatographic-mass spectrometric procedures. J Chromatogr 496 416-422 (1989).

Formal Name Techin
CAS Number 84807-87-4
Molecular Formula C20H24D8O3
Formula Weight 328.5
Formulation A solution in acetonitrile
Purity ≥99% deuterated product
λmax 236 nm
ε 27
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@H]​(O)​\C=C\C=C\C/C=C\C/C=C\CCCC(=O)​O

Background Reading

Nadel, J.A., Conrad, D.J., Ueki, I.F., et al. Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocyes, leukocytes, and airway cells. J Clin Invest 87 1139-1145 (1991).

Ramis, I., Roselló-Catafau, J., Bulbena, O., et al. 15-Hydroxyeicosatetraenoic acid as a major eicosanoid in nasal secretions: Assay by high-performance liquid chromatographic-radioimmunoassay and gas chromatographic-mass spectrometric procedures. J Chromatogr 496 416-422 (1989).

Funk, M.O., Carroll, R.T., Thompson, J.F., et al. The lipoxygenases in developing soybean seeds, their characterization and synthesis in vitro. Plant Physiol 82 1139-1144 (1986).
Size Price Quantity Subtotal
25 µg $101.00 $0.00
50 µg $192.00 $0.00
100 µg $364.00 $0.00
500 µg $1,616.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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