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Oxidized Lipid HPLC Mixture

Cayman Chemical Item Number 34004

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Description

This mixture contains the primary oxidized unsaturated fatty acid components of atherosclerotic plaques. Contents: (±)9-HODE, (±)13-HODE, (±)9-HODE cholesteryl ester, (±)13-HODE cholesteryl ester, and (±)15-HETE (5 µg each). Cholesterol and LDL particles accumulate and become oxidized in the fatty deposits of atherosclerotic placques. Contained within these lipid deposits are the racemic monohydroxylation products of both linoleic and arachidonic acid.1 This HPLC mixture contains the free acid (non-esterified) forms of racemic 15-HETE, 9-HODE, and 13-HODE. 15-HETE is one of 5 different regioisomers produced by the random oxygenation of arachidonic acid.2 (The other 4 can be purchased in HPLC Mixture Catalog. No. 34002.) The 9- and 13- HODEs are the 2 different monohydroxylated regioisomers of linoleic acid produced during random free radical oxidation. In this mixture, the HODE compounds are provided both in their free acid form, and also esterified to cholesterol. Linoleate is transported primarily as the cholesteryl ester in the LDL particle, and it is likely that the esterified form is oxidized when LDL particles are exposed to uncontrolled reactive oxygen species.3

1 Belkner, J., Wiesner, R., Kühn, H., et al. The oxygenation of cholesterol esters by the reticulocyte lipoxygenase. FEBS Lett 279 110-114 (1991).

2 Green, M.D., Xiao, L., and Lal, A.A. Formation of hydroxyeicosatetraenoic acids from hemozoin-catalyzed oxidation of arachidonic acid. Mol Biochem Parasitol 83 183-188 (1996).

3 Harland, W.A., Gilbert, J.D., and Brooks, C.J.W. Lipids of Human Atheroma. VIII. Oxidised derivatives of cholesteryl linoleate. Biochim Biophys Acta 316 378-385 (1973).

Formulation A solution in ethanol
Purity >98% for each compound
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Belkner, J., Wiesner, R., Kühn, H., et al. The oxygenation of cholesterol esters by the reticulocyte lipoxygenase. FEBS Lett 279 110-114 (1991).

Harland, W.A., Gilbert, J.D., and Brooks, C.J.W. Lipids of Human Atheroma. VIII. Oxidised derivatives of cholesteryl linoleate. Biochim Biophys Acta 316 378-385 (1973).

Green, M.D., Xiao, L., and Lal, A.A. Formation of hydroxyeicosatetraenoic acids from hemozoin-catalyzed oxidation of arachidonic acid. Mol Biochem Parasitol 83 183-188 (1996).
Size Price Quantity Subtotal
1 ea $92.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

(±)13-HODE
(±)13-HODE cholesteryl ester
(±)15-HETE
(±)9-HODE
(±)9-HODE cholesteryl ester
Arachidonic Acid
(±)-HETE HPLC Mixture
(S)-HETE HPLC Mixture
ω-3 Hydroxy Acid HPLC Mixture
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