Cayman Chemical | Oxidized Lipid HPLC Mixture

34004 Oxidized Lipid HPLC Mixture

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• See more Oxylipins; Atherosclerosis; Oxidative Injury

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This mixture contains the primary oxidized unsaturated fatty acid components of atherosclerotic plaques. Contents: (±)9-HODE, (±)13-HODE, (±)9-HODE cholesteryl ester, (±)13-HODE cholesteryl ester, and (±)15-HETE (5 µg each). Cholesterol and LDL particles accumulate and become oxidized in the fatty deposits of atherosclerotic placques. Contained within these lipid deposits are the racemic monohydroxylation products of both linoleic and arachidonic acid.¹ This HPLC mixture contains the free acid (non-esterified) forms of racemic 15-HETE, 9-HODE, and 13-HODE. 15-HETE is one of 5 different regioisomers produced by the random oxygenation of arachidonic acid.² (The other 4 can be purchased in HPLC Mixture Catalog. No. 34002.) The 9- and 13- HODEs are the 2 different monohydroxylated regioisomers of linoleic acid produced during random free radical oxidation. In this mixture, the HODE compounds are provided both in their free acid form, and also esterified to cholesterol. Linoleate is transported primarily as the cholesteryl ester in the LDL particle, and it is likely that the esterified form is oxidized when LDL particles are exposed to uncontrolled reactive oxygen species.³

1 Belkner, J., Wiesner, R., Kühn, H., et al. The oxygenation of cholesterol esters by the reticulocyte lipoxygenase. FEBS Lett 279 110-114 (1991).

2 Green, M.D., Xiao, L., Lal, A.A. Formation of hydroxyeicosatetraenoic acids from hemozoin-catalyzed oxidation of arachidonic acid. Mol Biochem Parasitol 83 183-188 (1996).

3 Harland, W.A., Gilbert, J.D., Brooks, C.J.W. Lipids of Human Atheroma. VIII. Oxidised derivatives of cholesteryl linoleate. Biochim Biophys Acta 316 378-385 (1973).

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Warning This product is not for human or veterinary use.

Pricing updated 2010-03-14.
Prices are subject to change without notice.

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