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(±)5-HETE lactone

Cayman Chemical Item Number 34215

(CAS 73279-37-5)

(±)5-HETE lactone (CAS 73279-37-5)

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Description

(±)5-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE. (±)5-HETE lactone is an inhibitor of 5-lipoxygenase from rat basophilic leukemia cells with an IC50 of 27 µM. The lactone is several times more potent than the linear (±)5-HETE.1

1 Kerdesky, F.A.J., Schmidt, S.P., Holms, J.H., et al. Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogues. J Med Chem 30 1177-1186 (1987).

Formal Name (±)5-​hydroxy-​6E,​8Z,​11Z,​14Z-​eicosatetraenoic acid,​ 1,​5-​lactone
CAS Number 73279-37-5
Molecular Formula C20H30O2
Formula Weight 302.5
Formulation A solution in acetonitrile
Purity ≥98%
λmax 236 nm
ε 27
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\C/C=C\C=C/C1CCCC(=O)​O1

Background Reading

Kerdesky, F.A.J., Schmidt, S.P., Holms, J.H., et al. Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogues. J Med Chem 30 1177-1186 (1987).

(±)5-HETE lactone is available in the following screening library:

Size Price Quantity Subtotal
25 µg $35.00 $0.00
50 µg $67.00 $0.00
100 µg $126.00 $0.00
500 µg $560.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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