Cayman Chemical | (±)5-HETE lactone | Description (CAS 73279-37-5)

34215 (±)5-HETE lactone

(CAS 73279-37-5)

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• See more Inhibitors; Lipoxygenase; Oxylipins; Oxidative Injury

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(±)5-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE. (±)5-HETE lactone is an inhibitor of 5-lipoxygenase from rat basophilic leukemia cells with an IC₅₀ of 27 µM. The lactone is several times more potent than the linear (±)5-HETE.¹

1 Kerdesky, F.A.J., Schmidt, S.P., Holms, J.H., et al. Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogues. J Med Chem 30 1177-1186 (1987).

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Purchase 34215 (±)5-HETE lactone

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Pricing updated 2010-03-13.
Prices are subject to change without notice.

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