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5(R)-HETE

Cayman Chemical Item Number 34225

(CAS 61641-47-2)

5(R)-HETE (CAS 61641-47-2)

See more	Lipoxygenase (84) Oxylipins (227)

Description

5(R)-HETE is a rare lipoxygenase product of arachidonic acid. Nearly all plant and animal 5-LOs produce 5(S)-HETE, but the presence of a 5(R)-LO and the synthesis of 5(R)-HpETE and 5(R)-HETE have been confirmed in oocytes of the bivalve mollusk, S. solidissima.¹ 5(R)-HETE is more potent than the (S)-enantiomer as a chemotactic agent for human neutrophils.²

1 Hada, T., Swift, L.L., and Brash, A.R. Discovery of 5R-lipoxygenase activity in oocytes of the surf clam, Spisula solidissima. Biochim Biophys Acta 1346 109-119 (1997).

2 Bittleman, D.B., and Casale, T.B. 5-Hydroxyeicosatetraenoic acid (HETE)-induced neutrophil transcellular migration is dependent upon enantiomeric structure. Am J Respir Cell Mol Biol 12 260-267 (1995).

Formal Name	5R-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid
CAS Number	61641-47-2
Molecular Formula	C₂₀H₃₂O₃
Formula Weight	320.5
Formulation	A solution in ethanol
Purity	≥98%
λ_max	236 nm
ε	27
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCC1=C(C/C=C\C/C=C\C=C/C(O)CCCC(=O)O)C1

Background Reading

Bittleman, D.B., and Casale, T.B. 5-Hydroxyeicosatetraenoic acid (HETE)-induced neutrophil transcellular migration is dependent upon enantiomeric structure. Am J Respir Cell Mol Biol 12 260-267 (1995).

Hada, T., Swift, L.L., and Brash, A.R. Discovery of 5R-lipoxygenase activity in oocytes of the surf clam, Spisula solidissima. Biochim Biophys Acta 1346 109-119 (1997).

Size	Price	Quantity	Subtotal
25 µg	$69.00		$0.00
50 µg	$131.00		$0.00
100 µg	$248.00		$0.00
250 µg	$552.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

(±)5-HETE

(±)5-HETE lactone

5(S)-HETE

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