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5(S)-HETE

Cayman Chemical Item Number 34230

(CAS 70608-72-9)

5(S)-HETE (CAS 70608-72-9)

See more	Lipoxygenase (84) Oxylipins (226)

Description

5(S)-HETE is produced by the action of 5-LO on arachidonic acid to give 5(S)-HpETE, followed by reduction of the hydroperoxide. 5(S)-HETE has proliferative and chemotactic effects on granulocytes.¹ When further metabolized to 5-oxoETE, it is a more potent eosinophil chemoattractant than leukotriene B₄.^2,3

1 Dodge, W., and Thomas, M. The effect of 5-hydroxyeicosatetraenoic acid on the proliferation of granulocyte progenitors and embryonic fibroblasts of the chick. Biochem Biophys Res Commun 131 731-735 (1985).

2 Schwenk, U., and Schröder, J. 5-oxo-Eicosanoids are potent eosinophil chemotactic factors. J Biol Chem 270 15029-15036 (1994).

3 Powell, W.S., Gravelle, F., and Gravel, S. Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes. J Biol Chem 267 19233-19241 (1992).

Formal Name	5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid
CAS Number	70608-72-9
Molecular Formula	C₂₀H₃₂O₃
Formula Weight	320.5
Formulation	A solution in ethanol
Purity	≥98%
λ_max	236 nm
ε	27
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC/C=C\C/C=C\C/C=C\C=C/[C@@H](O)CCCC(=O)O

Background Reading

Dodge, W., and Thomas, M. The effect of 5-hydroxyeicosatetraenoic acid on the proliferation of granulocyte progenitors and embryonic fibroblasts of the chick. Biochem Biophys Res Commun 131 731-735 (1985).

Powell, W.S., Gravelle, F., and Gravel, S. Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes. J Biol Chem 267 19233-19241 (1992).

Schwenk, U., and Schröder, J. 5-oxo-Eicosanoids are potent eosinophil chemotactic factors. J Biol Chem 270 15029-15036 (1994).

5(S)-HETE is available in the following screening library:

Bio-active Lipid II Screening Library (96-Well)

Size	Price	Quantity	Subtotal
25 µg	$83.00		$0.00
50 µg	$158.00		$0.00
100 µg	$299.00		$0.00
250 µg	$664.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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5(S)-HETE lactone

5(S)-HETE Lipid Maps MS Standard

5(S)-HpETE

Leukotriene B₄

(S)-HETE HPLC Mixture

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