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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

15(S)-HETE-biotin

Cayman Chemical Item Number 34722

15(S)-HETE-biotin

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Description

15(S)-HETE is a major arachidonic acid metabolite produced by the 15-lipoxygenase pathway. It has been characterized as a potent inhibitor of 5-lipoxygenase.1,2 The mechanism by which 15(S)-HETE acts as a leukotriene inhibitor is not clear. In studies with P-18 mast/basophil cells, it was shown that specific 15-HETE receptors, rather than esterification, appeared to be involved in signal transduction.3 15(S)-HETE-biotin can be used to detect 15(S)-HETE binding proteins and/or receptors.4

1 Kang, L., and Vanderhoek, J.Y. Characterization of specific subcellular 15-hydroxyeicosatetraenoic acid (15-HETE) binding sites on rat basophilic leukemia cells. Biochim Biophys Acta 1256 297-304 (1995).

2 Vanderhoek, J.Y., Bryant, R.W., and Bailey, J.M. Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid. J Biol Chem 255 10064-10065 (1980).

3 Vonakis, B.M., and Vanderhoek, J.Y. 15-Hydroxyeicosatetraenoic acid (15-HETE) receptors. J Biol Chem 267 23625-23631 (1992).

4 Kang, L., and Vanderhoek, J.Y. Synthesis and use of a novel biotinylated probe for the chemiluminescent detection of proteins that bind 15-hydroxyeicosatetraenoic acid. Anal Biochem 250 119-122 (1997).

Formal Name 15S-​hydroxy-​5Z,​8Z,​11Z,​13E-​eicosatetraene-​(2-​biotinyl)hydrazide
Molecular Formula C30H48N4O4S
Formula Weight 560.8
Formulation A solution in ethanol
Purity ≥98% (may contain trace amounts of free biotin)
λmax 236 nm
ε 23
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCC(O)​\C=C\C=C\C/C=C\C/C=C\CCCC(=O)​NNC(=O)​CCCCC1SCC2NC(=O)​NC12

Background Reading

Vanderhoek, J.Y., Bryant, R.W., and Bailey, J.M. Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid. J Biol Chem 255 10064-10065 (1980).

Kang, L., and Vanderhoek, J.Y. Synthesis and use of a novel biotinylated probe for the chemiluminescent detection of proteins that bind 15-hydroxyeicosatetraenoic acid. Anal Biochem 250 119-122 (1997).

Vonakis, B.M., and Vanderhoek, J.Y. 15-Hydroxyeicosatetraenoic acid (15-HETE) receptors. J Biol Chem 267 23625-23631 (1992).

Kang, L., and Vanderhoek, J.Y. Characterization of specific subcellular 15-hydroxyeicosatetraenoic acid (15-HETE) binding sites on rat basophilic leukemia cells. Biochim Biophys Acta 1256 297-304 (1995).

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Size Price Quantity Subtotal
25 µg $102.00 $0.00
50 µg $194.00 $0.00
100 µg $367.00 $0.00
250 µg $816.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

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15(S)-HETE

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