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6-trans Leukotriene B₄

Cayman Chemical Item Number 35250

All trans LTB₄; 5(S),12(R)-DiHETE; 6-trans LTB₄ (CAS 71652-82-9)

6-trans Leukotriene B4 (CAS 71652-82-9)

See more	Leukotrienes (90)

Description

6-trans LTB₄ is produced by the non-enzymatic hydrolysis of LTA₄.¹ Oxidative decomposition of cysteinyl-leukotrienes such as LTC₄ in the presence of myeloperoxidase and hypochlorous acid can also produce 6-trans LTB₄, but the physiologic importance of this mechanism is not clear.² 6-trans LTB₄ is relatively inactive compared to LTB₄, but chemoattractant properties in neutrophils have been reported.³

1 Borgeat, P., and Samuelsson, B. Metabolism of arachidonic acid in polymorphonuclear leukocytes. J Biol Chem 254 7865-7869 (1979).

2 Lee, C.W., Lewis, R.A., Tauber, A.I., et al. The myeloperoxidase-dependent metabolism of leukotrienes C₄, D₄, and E₄ to 6-trans-leukotriene B₄ diastereoisomers and the subclass-specific S-diastereoisomeric sulfoxides. J Biol Chem 258 15004-15010 (1983).

3 Fretland, D.J., Widomski, D.L., Anglin, C.P., et al. 6-trans-Leukotriene B₄ is a neutrophil chemotoxin in the guinea pig dermis. J Leukoc Biol 49 283-288 (1991).

Synonyms	All trans LTB4 5(S),12(R)-DiHETE 6-trans LTB4
Formal Name	5S,12R-dihydroxy-6E,8E,10E,14Z-eicosatetraenoic acid
CAS Number	71652-82-9
Molecular Formula	C₂₀H₃₂O₄
Formula Weight	336.5
Formulation	A solution in ethanol
Purity	≥97%
λ_max	269 nm
ε	50
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC/C=C\C[C@@H](O)/C=C/C=C/C=C/[C@@H](O)CCCC(O)=O

Background Reading

Fretland, D.J., Widomski, D.L., Anglin, C.P., et al. 6-trans-Leukotriene B₄ is a neutrophil chemotoxin in the guinea pig dermis. J Leukoc Biol 49 283-288 (1991).

Borgeat, P., and Samuelsson, B. Metabolism of arachidonic acid in polymorphonuclear leukocytes. J Biol Chem 254 7865-7869 (1979).

Lee, C.W., Lewis, R.A., Tauber, A.I., et al. The myeloperoxidase-dependent metabolism of leukotrienes C₄, D₄, and E₄ to 6-trans-leukotriene B₄ diastereoisomers and the subclass-specific S-diastereoisomeric sulfoxides. J Biol Chem 258 15004-15010 (1983).

6-trans Leukotriene B4 is available in the following screening library:

Bio-active Lipid II Screening Library (96-Well)

Size	Price	Quantity	Subtotal
25 µg	$86.00		$0.00
50 µg	$163.00		$0.00
100 µg	$310.00		$0.00
250 µg	$688.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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6-trans Leukotriene B4