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6-trans-12-epi Leukotriene B₄

Cayman Chemical Item Number 35265

5(S),12(S)-DiHETE; 6-trans-12-epi LTB₄ (CAS 71548-19-1)

6-trans-12-epi Leukotriene B4 (CAS 71548-19-1)

See more	Leukotrienes (90)

Description

6-trans-12-epi Leukotirene B₄ (LTB₄) is a non-enzymatic hydrolysis product of LTA₄. It was originally isolated from glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNL).^1,2 6-trans-12-epi LTB₄ is weakly chemotactic for PMNL, with approximately 20 times less potency than LTB₄, and has no effect on the aggregation response.³

1 Borgeat, P., and Samuelsson, B. Metabolism of arachidonic acid in polymorphonuclear leukocytes. J Biol Chem 254 7865-7869 (1979).

2 Borgeat, P., and Samuelsson, B. Arachidonic acid metabolism in polymorphonuclear leukocytes: Unstable intermediate in formation of dihydroxy acids. Proc Natl Acad Sci USA 76 3213-3217 (1979).

3 Lee, T.H., Mencia-Huerta, J.M., Shih, C., et al. Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product. J Biol Chem 259 2383-2389 (1984).

Synonyms	5(S),12(S)-DiHETE 6-trans-12-epi LTB4
Formal Name	5S,12S-dihydroxy-6E,8E,10E,14Z-eicosatetraenoic acid
CAS Number	71548-19-1
Molecular Formula	C₂₀H₃₂O₄
Formula Weight	336.5
Formulation	A solution in ethanol
Purity	≥97%
λ_max	268 nm
ε	50
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC/C=C\CC(O)/C=C/C=C\C=C/C(O)CCCC(=O)O

Background Reading

Borgeat, P., and Samuelsson, B. Arachidonic acid metabolism in polymorphonuclear leukocytes: Unstable intermediate in formation of dihydroxy acids. Proc Natl Acad Sci USA 76 3213-3217 (1979).

Lee, T.H., Mencia-Huerta, J.M., Shih, C., et al. Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product. J Biol Chem 259 2383-2389 (1984).

Borgeat, P., and Samuelsson, B. Metabolism of arachidonic acid in polymorphonuclear leukocytes. J Biol Chem 254 7865-7869 (1979).

Size	Price	Quantity	Subtotal
25 µg	$86.00		$0.00
50 µg	$163.00		$0.00
100 µg	$310.00		$0.00
250 µg	$688.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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6-trans-12-epi Leukotriene B4