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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

5(S),15(S)-DiHETE

Cayman Chemical Item Number 35280

(CAS 82200-87-1)

5(S),15(S)-DiHETE (CAS 82200-87-1)

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Description

5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE.1 It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4.2 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 µM.3

1 Green, F.A. Transformations of 5-HETE by activated keratinocyte 15-lipoxygenase and the activation mechanism. Lipids 25 618-623 (1990).

2 O'Flaherty, J.T., and Thomas, M.J. Effect of 15-lipoxygenase-deprived arachidonate metabolites on human neutrophil degranulation. Prostaglandins Leukot Med 17 199-212 (1985).

3 Morita, E., Schröder, J., and Christophers, E. Identification of a novel and highly potent eosinophil chemotactic lipid in human eosinophils treated with arachidonic acid. J Immunol 144 1893-1900 (1990).

Formal Name 5S,​15S-​dihydroxy-​6E,​8Z,​10Z,​13E-​eicosatetraenoic acid
CAS Number 82200-87-1
Molecular Formula C20H32O4
Formula Weight 336.5
Formulation A solution in ethanol
Purity ≥98%
λmax 243 nm
ε 33
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@H]​(O)​/C=C/C=C\C/C=C\C=C\[C@@H]​(O)​CCCC(O)​=O

Background Reading

Green, F.A. Transformations of 5-HETE by activated keratinocyte 15-lipoxygenase and the activation mechanism. Lipids 25 618-623 (1990).

Morita, E., Schröder, J., and Christophers, E. Identification of a novel and highly potent eosinophil chemotactic lipid in human eosinophils treated with arachidonic acid. J Immunol 144 1893-1900 (1990).

O'Flaherty, J.T., and Thomas, M.J. Effect of 15-lipoxygenase-deprived arachidonate metabolites on human neutrophil degranulation. Prostaglandins Leukot Med 17 199-212 (1985).

5(S),15(S)-DiHETE is available in the following screening library:

Size Price Quantity Subtotal
25 µg $69.00 $0.00
50 µg $131.00 $0.00
100 µg $248.00 $0.00
250 µg $552.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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