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8(S),15(S)-DiHETE

Cayman Chemical Item Number 35370

(CAS 80234-65-7)

8(S),15(S)-DiHETE (CAS 80234-65-7)

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Description

8(S),15(S)-DiHETE is formed when 15(S)-HETE is subjected to further oxidation by 15-LO.1 It causes eosinophil chemotaxis with an ED50 value of 1.5 µM but is not chemotactic for neutrophils. 8(S),15(S)-DiHETE antagonizes the hyperalgesic activity of 8(R),15(S)-DiHETE and LTB4 in the rat hind paw pain model.2

1 Morita, E., Schröder, J., and Christophers, E. Identification of a novel and highly potent eosinophil chemotactic lipid in human eosinophils treated with arachidonic acid. J Immunol 144 1893-1900 (1990).

2 Levine, J.D., Lam, D., Taiwo, Y.O., et al. Hyperalgesic properties of 15-lipoxygenase products of arachidonic acid. Proc Natl Acad Sci USA 83 5331-5334 (1986).

Formal Name 8S,​15S-​dihydroxy-​5Z,​9E,​11Z,​13E-​eicosatetraenoic acid
CAS Number 80234-65-7
Molecular Formula C20H32O4
Formula Weight 336.5
Formulation A solution in ethanol
Purity ≥98%
λmax 268 nm
ε 40
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@H]​(O)​/C=C/C=C\C=C\[C@@H]​(O)​C/C=C\CCCC(O)​=O

Background Reading

Levine, J.D., Lam, D., Taiwo, Y.O., et al. Hyperalgesic properties of 15-lipoxygenase products of arachidonic acid. Proc Natl Acad Sci USA 83 5331-5334 (1986).

Morita, E., Schröder, J., and Christophers, E. Identification of a novel and highly potent eosinophil chemotactic lipid in human eosinophils treated with arachidonic acid. J Immunol 144 1893-1900 (1990).

8(S),15(S)-DiHETE is available in the following screening library:

Size Price Quantity Subtotal
25 µg $69.00 $0.00
50 µg $131.00 $0.00
100 µg $248.00 $0.00
250 µg $552.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

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5(S),15(S)-DiHETE
5(S),6(R)-11-trans DiHETE

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