Peptide sequence: ovine COX-1 amino acids 272-282 (LMHYPRGIPPQ) · To be used in conjunction with Cayman’s COX-1 (ovine) polyclonal antiserum (Catalog No. 160108) to block protein-antibody complex formation during analysis for COX-1.

DeWitt, D.L. Prostaglandin endoperoxide synthase: Regulation of enzyme expression. Biochim Biophys Acta 1083 121-134 (1991).

Hla, T., and Maciag, T. Cyclooxygenase gene expression is down-regulated by heparin-binding (acidic fibroblast) growth factor-1 in human endothelial cells. J Biol Chem 266 24059-24063 (1991).

Funk, C.D., Funk, L.B., Kennedy, M.E., et al. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J 5 2304-2312 (1991).

Xie, W., Robertson, D.L., and Simmons, D.L. Mitogen-inducible prostaglandin G/H synthase: A new target for nonsteroidal antiinflammatory drugs. Drug Dev Res 25 249-265 (1992).

Otto, J.C., and Smith, W.L. The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum. J Biol Chem 269 19868-19875 (1994).

Smith, W.L., and DeWitt, D.L. Prostaglandin endoperoxide H synthases-1 and -2. Adv Immunol 62 167-215 (1995).

Brannon, T.S., North, A.J., Wells, L.B., et al. Prostacyclin synthesis in ovine pulmonary artery is developmentally regulated by changes in cyclooxygenase-1 gene expression. J Clin Invest 93 2230-2235 (1994).

Samet, J.M., Fasano, M.B., Fonteh, A.N., et al. Selective induction of prostaglandin G/H synthase I by stem cell factor and dexamethasone in mast cells. J Biol Chem 270 8044-8049 (1995).

DeWitt, D.L., and Smith, W.L. Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence. Proc Natl Acad Sci USA 85 1412-1416 (1988).

DeWitt, D.L., El-Harith, E.A., Kraemer, S.A., et al. The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases. J Biol Chem 265 5192-5198 (1990).

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