Prostaglandin E Synthase-1 (microsomal) Blocking Peptide

Cayman Chemical Item Number 360140

mPGES-1; Prostaglandin H/E Isomerase-1; PIG12; PGES-1; PGE Synthase-1; Membrane-Associated PGES-1; MGST1-L1

Description

Peptide sequence: human amino acids 59-75 (CRSDPDVERSLRAHRND) · To be used in conjunction with Cayman’s microsomal PGE synthase-1 polyclonal antibody (Catalog No. 160140) to block protein-antibody complex formation during analysis for microsomal PGE synthase.

Synonyms

mPGES-1
Prostaglandin H/E Isomerase-1
PIG12
PGES-1
PGE Synthase-1
Membrane-Associated PGES-1
MGST1-L1

Formulation

A lyophilized peptide

Stability

2 years

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Background Reading

Robert, A., Schultz, J.R., Nezamis, J.E., et al. Gastric antisecretory and antiulcer properties of PGE₂, 15-methyl PGE₂, and 16,16-dimethyl PGE₂. Intravenous, oral and intrajejunal administration. Gastroenterology 70 359-370 (1976).

Jackson, G.M., Sharp, H.T., and Varner, M.W. Cervical ripening before induction of labor: A randomized trial of prostaglandin E₂ gel versus low-dose oxytocin. Am J Obstet Gynecol 171 1092-1096 (1994).

Arvind, P., Papavassiliou, E.D., Tsioulias, G.J., et al. Prostaglandin E₂ down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell lines. Biochemistry 34 5604-5609 (1995).

Willis, A.L., and Cornelsen, M. Repeated injection of prostaglandin E₂ in rat paws induces chronic swelling and a marked decrease in pain threshold. Prostaglandins 3 353-357 (1973).

Jakobsson, P., Thorén, S., Morgenstern, R., et al. Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci USA 96 7220-7225 (1999).

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